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  4. Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA), partial

Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA), partial

In Stock
  • 中文名稱(chēng)：
    Recombinant Porphyromonas gingivalis Gingipain R1(rgpA),partial
  • 貨號(hào)：
    CSB-YP338957PQP
  • 規(guī)格：
    ￥2616
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338957PQP could indicate that this peptide derived from Yeast-expressed Porphyromonas gingivalis rgpA.
    • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP338957PQP could indicate that this peptide derived from Yeast-expressed Porphyromonas gingivalis rgpA.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    rgpA
  • Uniprot No.：
  • 別名：
    rgpA; rgp1Gingipain R1; EC 3.4.22.37; Arg-gingipain; Gingipain 1; RGP-1
  • 種屬：
    Porphyromonas gingivalis
  • 蛋白長(zhǎng)度：
    Partial
  • 來(lái)源：
    Yeast
  • 分子量：
    56.0kDa
  • 表達(dá)區(qū)域：
    228-720aa
  • 氨基酸序列
    YTPVEEKQNGRMIVIVAKKYEGDIKDFVDWKNQRGLRTEVKVAEDIASPVTANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIVGNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIASAEGGPSADNGESDIQHENVIANLLTQYGYTKIIKCYDPGVTPKNIIDAFNGGISLVNYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFLFSMPCFAEALMRAQKDGKPTGTVAIIASTINQSWASPMRGQDEMNEILCEKHPNNIKRTFGGVTMNGMFAMVEKYKKDGEKMLDTWTVFGDPSLLVRTLVPTKMQVTAPAQINLTDASVNVSCDYNGAIATISANGKMFGSAVVENGTATINLTGLTNESTLTLTVVGYNKETVIKTINTNGEPNPYQPVSNLTATTQGQKVTLKWDAPSTKTNATTNTARSVDGIRELVLLSVSDAPELLRS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：
        Recombinant Porphyromonas gingivalis Gingipain R1 (rgpA)是一種經(jīng)重組制備的齦炎擬桿菌（Porphyromonas gingivalis）Gingipain R1蛋白。rgpA是齦炎擬桿菌中的一個(gè)重要分泌蛋白酶，對(duì)牙周疾病的發(fā)生和進(jìn)展起著關(guān)鍵作用。
        牙周疾病是一類(lèi)常見(jiàn)的口腔疾病，包括牙齦炎和牙周炎等。rgpA作為齦炎擬桿菌中主要的蛋白酶，可以降解牙周組織中的膠原蛋白和其他關(guān)鍵蛋白質(zhì)，導(dǎo)致牙周組織的破壞和炎癥反應(yīng)的加劇。
        華美生物酵母表達(dá)系統(tǒng)所表達(dá)的重組rgpA蛋白，表達(dá)區(qū)域?yàn)?14-634aa，具有良好的穩(wěn)定性和純度，可廣泛應(yīng)用于實(shí)驗(yàn)室研究中，如分子生物學(xué)實(shí)驗(yàn)、蛋白質(zhì)相互作用研究等。研究rgpA的功能和調(diào)控機(jī)制有助于我們更深入地了解牙周疾病的發(fā)生和發(fā)展過(guò)程，為新的牙周炎治療策略的開(kāi)發(fā)提供理論基礎(chǔ)。此外，rgpA的研究也對(duì)開(kāi)發(fā)新的抗菌藥物和預(yù)防措施提供了新的靶點(diǎn)。
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defense mechanisms (Probable).
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase C25 family