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  4. Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial

Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C), partial

  • 中文名稱：
    Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial
  • 貨號：
    CSB-YP004399RB
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial
  • 貨號：
    CSB-EP004399RB
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial
  • 貨號：
    CSB-EP004399RB-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial
  • 貨號：
    CSB-BP004399RB
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial
  • 貨號：
    CSB-MP004399RB
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CACNA1C; CACH2; CACN2; CACNL1A1; CCHL1A1Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Smooth muscle calcium channel blocker receptor; CACB-receptor; Voltage-gated calcium channel subunit alpha Cav1.2
  • 種屬：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
  • 基因功能參考文獻：
    1. (CaV1.2 alpha-1) Cav1.2 alpha-1 binds specifically to CaMKII in forebrain to enhance regulatory phosphorylation. PMID: 19840220
    2. a model where high affinity binding of Ca(V)beta to the I-II linker of Ca(V)alpha1 largely accounts for Ca(V)beta-induced plasma membrane targeting of Ca(V)1.2 PMID: 20478999
    3. The identification of seven PKC phosphorylation sites within the alpha(1c) subunit, is reported. PMID: 19527072
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendrite. Cell membrane, sarcolemma, T-tubule.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily
  • 組織特異性：
    Expression in cardiac muscle. In lung, expressed in airway and vascular smooth muscle cells.
  • 數(shù)據(jù)庫鏈接：

    KEGG: ocu:100101555

    UniGene: Ocu.1835