搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Cocaine- and amphetamine-regulated transcript protein (Cartpt)

Recombinant Rat Cocaine- and amphetamine-regulated transcript protein (Cartpt)

  • 中文名稱：
    Recombinant Rat Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 貨號(hào)：
    CSB-YP004532RA
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 貨號(hào)：
    CSB-EP004532RA
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 貨號(hào)：
    CSB-EP004532RA-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 貨號(hào)：
    CSB-BP004532RA
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Cocaine- and amphetamine-regulated transcript protein(Cartpt)
  • 貨號(hào)：
    CSB-MP004532RA
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Cartpt
  • Uniprot No.：
  • 別名：
    Cartpt; CartCocaine- and amphetamine-regulated transcript protein [Cleaved into: CART(1-52); CART(55-102); CART(62-102)]
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    28-129
  • 氨基酸序列
    QED AELQPRALDI YSAVDDASHE KELPRRQLRA PGAVLQIEAL QEVLKKLKSK RIPIYEKKYG QVPMCDAGEQ CAVRKGARIG KLCDCPRGTS CNSFLLKCL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus.
  • 基因功能參考文獻(xiàn)：
    1. impaired CART mRNA expression in the anterior Paraventricular nucleus and Lateral hypothalamic area could be related to the aberrant feeding behaviour of dehydration-induced anorexic rats but not to their deregulated HPT axis function. PMID: 28984394
    2. The results indicate that Cocaine and Amphetamine-Regulated Transcript (CART) can directly affect the physiological release of hormones in pituitary cells of starved animals. PMID: 28300671
    3. As the observed results are in agreement with data regarding the CART mRNA and protein expression in the brain reward pathway in opioid addiction phases, it may be suggested that evaluation of CART peptide level in CSF or plasma could be a suitable marker which reflects the rises and falls of the peptide concentration in brain in the development of opioid addiction PMID: 27349817
    4. Results suggest that CART plays an important role in recognition memory and that these effects may be mediated by NMDA receptors-ERK signaling in the entorhinal/perirhinal -hippocampal circuit. PMID: 27258934
    5. CART is important for maintaining the beta-cell phenotype. PMID: 28237718
    6. Study found that the distribution and intensity of CART staining in the nodose ganglion looked identical in fed and fasted rats when observed under blinded conditions and the density of CART-positive profiles across the ganglion was not significantly different in fed and fasted rats. PMID: 27822503
    7. Cocaine- and amphetamine-regulated transcript (CART) mRNA and protein were both up-regulated in morphine-administered animals and also in the withdrawal group in the nucleus accumbens (NAc), striatum and prefrontal cortex (PFC). In the addicted group, CART mRNA and protein were both down-regulated in NAc and striatum. PMID: 26955782
    8. These findings suggest that islet-derived CART is involved, at least in part, in high glucose-potentiated pancreatic beta-cell function. PMID: 27823935
    9. These results suggest that endogenous CART might closely interact with the dopamine containing substantia nigra-striatal pathway which is known to profoundly influence the motor system PMID: 26771081
    10. The study gives rise to the assumption that high blood pressure can be a factor that intensifies CART secretion PMID: 26150151
    11. Results suggest that there might be two partly overlapping brain circuits involved in the neurobiology of binge eating, both driven by CART PMID: 26008155
    12. Results suggest that oxidative stress in the brain participates in regulating NPY/CART-mediated appetite control in amphetamine-treated rats. PMID: 25825358
    13. Elevated circulating progesterone concentration up-regulated NPY and down-regulated CART genes expression in hypothalamus of females and caused an increase in food intake and white adipose tissue mass. PMID: 24549602
    14. Renal vascular reactivity is associated with up regulation of renal endothelin receptors type A. PMID: 24989426
    15. Cart expression decreased in the arcuate nucleus of the hypothalamus in polydipsic rats. PMID: 24647922
    16. Acumbal-CART peptide reduces anxiety-like behavior in a dose-dependent manner. PMID: 25256086
    17. We demonstrated that renovascular hypertension alters the number and immunoreactivity of CART-containing cells in adrenal glands PMID: 25151991
    18. These data demonstrate that CART peptide-expressing neurons are belong to a sparcely branched neuronal system. PMID: 25552080
    19. CART peptide is effective in blunting dopaine- and cocaine-mediated locomoter activity in both males and females. PMID: 24630272
    20. CART is relevant to the regulation of homeostasis in the cardiovascular system and seems to be involved in renovascular hypertension. PMID: 24939825
    21. The orexigenic effects of omentin-1 could be related, at least in part, to decreased CART and CRH gene expression. PMID: 23538212
    22. factors secondary to obesity and/or diabetes rather than impaired CCK-1 receptor signaling may contribute to altered CART expression PMID: 23545074
    23. CART was detected in the extensive population of neurons, particularly within the myenteric plexuses all along the GI tract, and also in neuroendocrine cells, being especially numerous in the stomach and a few in the small intestine. PMID: 22887004
    24. This study demonistrated that CART mRNA regulation by acute morphine or cocaine in the nucleus accumbens does not seem predictive of addiction vulnerability. PMID: 23907376
    25. work suggests that CART is functional in inhibiting the cerebral I/R-induced ER stress and neuronal apoptosis by facilitating the transcription, synthesis and secretion of BDNF in a CREB-dependent way PMID: 23770418
    26. CART is a novel constituent of human and rat adipocytes and affects several biological processes central in both lipid- and glucose homeostasis PMID: 23318496
    27. Forced swim stress elicits region- and sex-specific changes in CART mRNA expression in hypothalamic nuclei. PMID: 22960117
    28. study was designed to reveal the projection patterns of lateral hypothalamic (LH), cocaine- and amphetamine-regulated transcript (CART) neurons to the dorsal raphe (DR) and/or the locus coeruleus (LC) in the rat. PMID: 23206801
    29. The effect of exogenous CART 55-102 on beta cell viability was examined. PMID: 23250745
    30. Cocaine- and amphetamine-regulated transcript increased the expression of GAP43 and fluoro-ruby fluorescence in the lesioned cortex. In conclusion, our data suggest that intranasal CART treatment facilitates neuroregeneration in stroke brain. PMID: 23211962
    31. activation of CARTergic neurons in stria to-nigral projections testifies on participation of CART-peptide in compensatory brain mechanisms at dopamine loss PMID: 23155622
    32. CART peptide in brain regions and adrenal glands regulates the hypothalamo-pituitary-adrenal system and sympatho-adrenal axis activity during stress responses. PMID: 22137563
    33. CART is expressed in climbing fiber bands in all four transverse zones of the rat cerebellum, reflecting species-specific compartmental features. PMID: 21452228
    34. Our findings indicate that CART gene expression is induced in a distinct temporal and spatial manner in forebrain PMID: 21903152
    35. Food deprivation for 48 h significantly increased neuropeptide Y mRNA level, and decreased that of proopiomelanocortin and cocaine-amphetamine regulated transcript, in the arcuate nucleus of female pups separated from their mothers. PMID: 21821286
    36. CART is involved in activation of the hypothalamo-hypophyseal axis and cardiovascular regulation in response to changes in extracellular volume and osmolality. PMID: 21539900
    37. Brain morphologic study serves as basis for the biological significance of lateral septal CART peptide in regulation of food intake. PMID: 20883668
    38. CART mRNA expression is increased in the arcuate nucleus (ARC) following food intake on a high-fat diet, which may stimulate release of hypothalamic orexigenic neuropeptides in the ARC of diabetic rats. PMID: 20626417
    39. CART is able to modulate hormonal profile in a non-starved rats; however, the modulatory effect depends on the CART administration method PMID: 21407156
    40. The CART innervation of dorsal raphe nucleus, locus coeruleus and ventrolateral periaqueductal gray may be involved in the central processing of neuropathic pain. PMID: 21167239
    41. CART signaling within the paraventricular thalamus inhibits drug-primed reinstatement of cocaine seeking. PMID: 20886038
    42. The results suggest that CARTp activation of ERK signals via the NMDA receptor in the spinal cord dorsal horn was age-dependent. PMID: 20595030
    43. study shows novel role for CART neuropeptide in inhibiting renewal of extinguished alcoholic beer seeking apparently by reducing reinstatement by acting selectively to reduce the incentive motivational properties of the reward associated training context PMID: 20528087
    44. CART immunoreactivity may identify postulated accessory preganglionic neurons whose actions in the rat may amplify vasomotor ganglionic transmission. PMID: 20810898
    45. These findings point to a potential novel role for CART in regulating wakefulness. PMID: 20116848
    46. Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. PMID: 19854189
    47. CART peptide is present in the NAcc to VP projection and likely plays a role in the motor functionality of the VP. PMID: 19825396
    48. Data found that BDNF, CART are colocalized in in the midbrain non-preganglionic Edinger-Westphal nucleus. Immunocytochemistry revealed a 16% lower number of BDNF-immunoreactive neurons, and 19% lower CART-immunoreactivity in females compared to males. PMID: 19755135
    49. results provide the first evidence that CARTp increases the phosphorylation of NMDA receptor NR1 subunit via activation of PKA and PKC signals, which may play a crucial role in CARTp regulation of spinal NMDA receptor-mediated nociceptive responses PMID: 19632277
    50. was detected in neurons of the rostral ventrolateral medulla (RVLM), but few in the caudal ventrolateral medulla (CVLM). PMID: 11841916

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    CART family
  • 組織特異性：
    Neuroendocrine tissues. Predominantly expressed in the hypothalamus, pituitary, and longitudinal muscle-myenteric plexus. Abundant expression is also seen in the midbrain/thalamus and eye. A lower level expression is seen in the other brain regions and ad
  • 數(shù)據(jù)庫(kù)鏈接：