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  4. Recombinant Rat Mevalonate kinase (Mvk)

Recombinant Rat Mevalonate kinase (Mvk)

  • 中文名稱(chēng)：
    大鼠Mvk重組蛋白
  • 貨號(hào)：
    CSB-YP015247RA
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱(chēng)：
    大鼠Mvk重組蛋白
  • 貨號(hào)：
    CSB-EP015247RA
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱(chēng)：
    大鼠Mvk重組蛋白
  • 貨號(hào)：
    CSB-EP015247RA-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱(chēng)：
    大鼠Mvk重組蛋白
  • 貨號(hào)：
    CSB-BP015247RA
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱(chēng)：
    大鼠Mvk重組蛋白
  • 貨號(hào)：
    CSB-MP015247RA
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mvk
  • Uniprot No.：
  • 別名：
    MvkMevalonate kinase; MK; EC 2.7.1.36
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-395
  • 氨基酸序列
    MLSEVLLVSA PGKVILHGEH AVVHGKVALA VALNLRTFLV LRPQSNGKVS LNLPNVGIKQ VWDVATLQLL DTGFLEQGDV PAPTLEQLEK LKKVAGLPRD CVGNEGLSLL AFLYLYLAIC RKQRTLPSLD IMVWSELPPG AGLGSSAAYS VCVAAALLTA CEEVTNPLKD RGSIGSWPEE DLKSINKWAY EGERVIHGNP SGVDNSVSTW GGALRYQQGK MSSLKRLPAL QILLTNTKVP RSTKALVAGV RSRLIKFPEI MAPLLTSIDA ISLECERVLG EMAAAPVPEQ YLVLEELMDM NQHHLNALGV GHASLDQLCQ VTAAHGLHSK LTGAGGGGCG ITLLKPGLER AKVEAAKQAL TGCGFDCWET SIGAPGVSMH SATSIEDPVR QALGL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. These results suggest that hCG-induced down-regulation of LHR mRNA expression is mediated by activation of cAMP/PKA/ERK pathways to increase miR-122 expression, which then increases LRBP expression through the activation of SREBPs. PMID: 24064360
    2. structure of rat mevalonate kinase in complex with MgATP has been determined at 2.4-A resolution PMID: 11877411
    3. results from kinetic studies showed the highly conserved histidine 20 is an important residue for the function of the enzyme PMID: 14680942
    4. Rat mevalonate kinase A141C variant enzyme has a new disulfide bond, which makes the variant protein enhance its thermal activity and resist to urea denaturation. PMID: 17964869
    5. Comparison of animal MK protein alignments and structures with those of a MK protein from Streptococcus pneumoniae indicates that sequence differences between N- and C-terminal domains correlate with differences in interdomain angles. PMID: 18302342

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  • 相關(guān)疾病：
    Mutation in the mevalonate kinase gene causes mevalonicaciduria.
  • 亞細(xì)胞定位：
    Cytoplasm. Peroxisome.
  • 蛋白家族：
    GHMP kinase family, Mevalonate kinase subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:81727

    UniGene: Rn.6995