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  4. Recombinant Rat Purkinje cell protein 4 (Pcp4)

Recombinant Rat Purkinje cell protein 4 (Pcp4)

  • 中文名稱：
    大鼠Pcp4重組蛋白
  • 貨號(hào)：
    CSB-YP017636RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pcp4重組蛋白
  • 貨號(hào)：
    CSB-EP017636RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pcp4重組蛋白
  • 貨號(hào)：
    CSB-EP017636RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pcp4重組蛋白
  • 貨號(hào)：
    CSB-BP017636RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pcp4重組蛋白
  • 貨號(hào)：
    CSB-MP017636RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Pcp4
  • Uniprot No.：
  • 別名：
    Pcp4; Pep19; Calmodulin regulator protein PCP4; Brain-specific polypeptide PEP-19; Purkinje cell protein 4
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-62
  • 氨基酸序列
    MSERQSAGAT NGKDKTSGDN DGQKKVQEEF DIDMDAPETE RAAVAIQSQF RKFQKKKAGS QS
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of PEP-19 suppresses angiotensin II-induced cardiomyocyte hypertrophy. PMID: 25048017
    2. These findings suggest that PEP 19-ir neurons in the MDH may have a function in modulation of nociceptive and thermo-receptive signaling. PMID: 22197496
    3. PCP4 promotes neuroendocrine cell differentiation and neurotransmitter release by activating calmodulin function. PMID: 21671256
    4. PEP-19 and LPI bind H1 histone mRNA and that this binding is affected by calmodulin. PMID: 22020791
    5. The novel rat-specific protein, tentatively named long PEP19 isoform (LPI), is the product of alternative splicing of the rat PCP4 gene encoding PEP19. PMID: 17273800
    6. Pcp4 osteoplastic differentiation of bone marrow mesenchymal stem cells is mediated in part via Pcp4-induced calcium deposition to form mineral nodules. PMID: 18008138
    7. PEP-19 degradation by calpain might produce an aberrant activation of calmodulin functions, which in turn causes neuronal cell death PMID: 18502590

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  • 蛋白家族：
    PCP4 family
  • 組織特異性：
    Restricted to the nervous system. Expressed throughout the brain, in particular forebrain regions, including the granular layer of the olfactory bulb, and pyriform cortex. Also expressed in the hippocampus, caudate putamen and the cerebellum, where it is
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