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  4. Recombinant Rat Sodium- and chloride-dependent glycine transporter 1 (Slc6a9), partial

Recombinant Rat Sodium- and chloride-dependent glycine transporter 1 (Slc6a9), partial

  • 中文名稱：
    大鼠Slc6a9重組蛋白
  • 貨號：
    CSB-YP021708RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Slc6a9重組蛋白
  • 貨號：
    CSB-EP021708RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Slc6a9重組蛋白
  • 貨號：
    CSB-EP021708RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Slc6a9重組蛋白
  • 貨號：
    CSB-BP021708RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Slc6a9重組蛋白
  • 貨號：
    CSB-MP021708RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Slc6a9
  • Uniprot No.：
  • 別名：
    Slc6a9; Sodium- and chloride-dependent glycine transporter 1; GlyT-1; GlyT1; Solute carrier family 6 member 9
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
  • 基因功能參考文獻：
    1. Study demonstrated a biphasic response of GlyT1 expression during epileptogenesis with initial downregulation of GlyT1 after epileptogenesis-precipitating seizures followed by sustained pathological overexpression of GlyT1 in chronic epilepsy PMID: 26302655
    2. Study showed that glycine uptake mediated by GlyT1 and GlyT2 in astrocytes is modulated by BDNF PMID: 26200505
    3. astrocytes express functional GlyT2, which challenge previous findings that those cells would express only GlyT1 PMID: 23529192
    4. Double labeling for GLYT1 and synaptophysin of this vesicular fraction revealed that more of ninety percent of them were synaptic vesicles PMID: 24036061
    5. Inhibition of GlyT1 reduces the frequency of spontaneous network events in the hippocampus. PMID: 25057202
    6. Glycine transport by GLYT1 is inhibited by lithium whereas GLYT2 transport is stimulated, and this effect is more evident at increased glycine concentrations. PMID: 21574997
    7. study analyzed transient currents of recombinant GlyT1b variant protein and related their properties to characteristics of steady transport currents; numerical simulations show a simplified, 3-state model explains main features of GlyT1b operation PMID: 19711201
    8. In conclusion, GlyT1 most likely mediates glycine transport at the inner BRB and is expected to play an important role in regulating the glycine concentration in the neural retina. PMID: 19666071
    9. findings suggest that loss of expression of the Glyt-1 transporter may cause an impairment of regulation of glycine concentration at synaptic level and contribute to an overactivation of the NMDA receptor in acute liver failure PMID: 12602503
    10. the close spatial association of GLYT1 and glutamatergic synapses strongly supports a role for this protein in neurotransmission PMID: 15749988
    11. These data underline the in vivo implication of the glycine uptake mechanism in the control of subcortical glutamate/dopamine interactions. PMID: 16289893
    12. post-translational mechanisms are of primary importance in elevating glycine transporter 1 protein levels following transient ischemia PMID: 17980459
    13. Data show the retina 1 expression of glycine transporter 1 in rats. PMID: 18695510
    14. Data show that dense GLYT1 expression is localized to superficial layer of microgyric cortex and around the microgyrus in the rat model of cortical dysplasia. PMID: 18775105
    15. Together, these results suggest PKCalpha to be a crucial factor in the regulation of glycine transport in C6 cells. PMID: 18778746
    16. These data support that treatment with a glycine transporter inhibitor can ameliorate deficits in both LTP and learning that occur in a rat model of psychosis, and may prove a useful strategy to address cognitive disruption in psychotic illnesses. PMID: 18973561
    17. Results show that endocytosis is impaired in an ubiquitination-deficient cell line. PMID: 19473961

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A9 subfamily
  • 組織特異性：
    Isoform 1 is only found in the white matter of the CNS. Isoform 2 is found in the gray matter of CNS as well as in macrophages and mast cells in peripherical tissues.
  • 數(shù)據(jù)庫鏈接：