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  4. Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase (Cyp17a1)

Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase (Cyp17a1)

  • 中文名稱：
    Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)
  • 貨號(hào)：
    CSB-EP006392RA
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cyp17a1; Cyp17Steroid 17-alpha-hydroxylase/17,20 lyase; EC 1.14.14.19; 17-alpha-hydroxyprogesterone aldolase; EC 1.14.14.32; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length
  • 來源：
    E.coli
  • 分子量：
    73.3kDa
  • 表達(dá)區(qū)域：
    1-507aa
  • 氨基酸序列
    MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that CYP17A1 and aromatase/Cyp19a1 are induced in hippocampus by the environmental pollutant/retinoid X receptor agonist tributyltin; thus, tributyltin appears to stimulate estradiol biosynthesis. PMID: 24679120
    2. Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (CYP17 and P450scc [cholesterol side-chain cleavage enzyme]) in ovarian tissue. PMID: 22798247
    3. these data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei of the rat PMID: 22800812
    4. Data demonstrate, for the first time, the presence and anatomical distribution of P450C(17) in the vestibular nuclei. PMID: 21388459
    5. Dibromoacetic acid can directly target rat Leydig cells and downregulate testicular CYP17 expression with a resulting decreased testicular testosterone production. PMID: 21046364
    6. immunolocalization of 3beta-hydroxysteroid dehydrogense, cytochrome P450c17 and androgen receptor were investigated in rat cumuli oophori of late pre-ovulatory follicles and in post-ovulatory COCs bearing fertilized oocytes PMID: 19775733
    7. Results suggest that PCB126 may affect testicular steroidogenesis by downregulating P450(17alpha), P450(scc) and have inhibitory effect on the testicular functions. PMID: 20356859
    8. 17beta-estradiol is synthesized by P45017alpha and P450 aromatase localized in hippocampal neurons from endogenous cholesterol PMID: 14694190
    9. CYP17 is expressed in rat kidney throughout the life-span and has a role in autonomous hormonal steroidogenesis PMID: 15261307
    10. Cyp17a1 in beta-cells of rat pancreas and its local steroidogenesis are reported. PMID: 18556192
    11. GDF-9 plays an important role in promoting preantral follicle growth by up-regulating follicular androgen biosynthesis. GDF-9 is essential for CYP17A1 expression during follicular development from the preantral to the early antral stage. PMID: 19213837
    12. The expression of the mouse CYP17A1 gene is epigenetically controlled. PMID: 19403566

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  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane. Microsome membrane.
  • 蛋白家族：
    Cytochrome P450 family
  • 數(shù)據(jù)庫鏈接：