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  4. Recombinant Rat Superoxide dismutase [Mn], mitochondrial (Sod2)

Recombinant Rat Superoxide dismutase [Mn], mitochondrial (Sod2)

  • 中文名稱：
    大鼠Sod2重組蛋白
  • 貨號(hào)：
    CSB-YP362262RA
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Sod2重組蛋白
  • 貨號(hào)：
    CSB-EP362262RA
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Sod2重組蛋白
  • 貨號(hào)：
    CSB-EP362262RA-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Sod2重組蛋白
  • 貨號(hào)：
    CSB-BP362262RA
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Sod2重組蛋白
  • 貨號(hào)：
    CSB-MP362262RA
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sod2; Superoxide dismutase [Mn]; mitochondrial; EC 1.15.1.1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    25-222
  • 氨基酸序列
    KHSLPD LPYDYGALEP HINAQIMQLH HSKHHATYVN NLNVTEEKYH EALAKGDVTT QVALQPALKF NGGGHINHSI FWTNLSPKGG GEPKGELLEA IKRDFGSFEK FKEKLTAVSV GVQGSGWGWL GFNKEQGRLQ IAACSNQDPL QGTTGLIPLL GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVSQRYIVC KK
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • 基因功能參考文獻(xiàn)：
    1. The SIRT3-SOD2 signaling pathway is involved in mitochondrial dysfunction induced by hemorrhagic shock PMID: 27067422
    2. These benefits appear to be attributed to the enhanced interaction between STAT3 and MnSOD. These findings shed a light on a new role of STAT3 in oxidative stress and suggest that ZYZ451 is likely an effective cardio-protective agent. PMID: 26721595
    3. SOD2 mediates amifostine-induced protection in PC12 cells exposed to glutamate. PMID: 26770652
    4. Selective upregulation of SOD2 in the left ventricles of rat hearts during L-NAME induced heart failure. PMID: 25978844
    5. SOD2 might regulate neuroinflammation by controlling the microglial activities. PMID: 26231211
    6. Study demonstrated that knockdown of MnSOD in vitro leads to reactive oxygene species generation as well as induction of functional mitochondrial biogenesis. PMID: 24563852
    7. Data indicate a functionally active mitochondrial pool of p38beta mitogen activated protein kinase (p38beta MAPK), and that this kinase phosphorylates manganese superoxide dismutase (MnSOD) in an 17beta-estradiol (E2)-dependent manner. PMID: 24465521
    8. Data suggest that expression of mitochondrial MnSOD/Sod2 (and CuZnSOD/Sod1) is down-regulated as retinal neurons undergo apoptosis following onset of diabetes/diabetic retinopathy. PMID: 24527463
    9. miR-146a could down-regulate the SOD2 protein expression. PMID: 23935993
    10. Hyperbaric oxygen therapy alters SOD2 protein and mRNA levels after brain injury in a time-dependent manner. PMID: 23275324
    11. The present findings suggest that oxidative stress occurring in the brain of immature rats during and following the seizures induced by DL-HCA is apparently due to both the increased free radical production and the limited antioxidant defense. PMID: 23238024
    12. Down-regulation of Mn-SOD expression may play an important role in the aggravation of oxidative stress in endemic fluorosis. PMID: 23157833
    13. SOD2 protects cardiac progenitor cells from apoptosis following xanthine/xanthine oxidase treatment. PMID: 22758933
    14. There was no difference in the expression of Mn-SOD between OLETF rats and LETO rats in type 2 diabetes. PMID: 22981416
    15. Data suggest that local overexpression of MnSOD in rat skeletal muscle in vivo (by electroporation to transfer the human gene) is sufficient to protect muscle against insulin resistance caused by oxidative stress of high-fat diet. PMID: 22829583
    16. Only the chronic administration of higher doses of alpha-tocopherol is associated with the increased activity and expression of Mn-SOD in rats. PMID: 22732938
    17. The increased expression of antioxidant SOD2, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. PMID: 21942371
    18. Berry diets did not alter COX-2 levels, but blueberry diet significantly reduced MnSOD levels in rats with reflux-induced esophageal adenocarcinoma. PMID: 22043833
    19. Changes in Mn-superoxide dismutase expression in rat hippocampus induced by single and triple exposure to moderate hypobaric hypoxia PMID: 22171425
    20. Upregulation of MnSOD in the aging heart was directly associated with attenuated levels of oxidative stress, including iNOS. PMID: 19297546
    21. Cigarette smoke aggravates reflux-induced BE and potentially accelerates the progression of BE to EAC through the loss of manganese superoxide dismutase (MnSOD), and overexpression of NF-kappaB- and COX-2-mediated factors. PMID: 21506880
    22. Increased H4K20me3 at sod2 contributes to its downregulation and is important in the development of diabetic retinopathy and in the metabolic memory phenomenon. PMID: 21357467
    23. Results suggest that the upregulation of TNFalpha, NFkappaB and MnSOD after deafferentation in the vestibular nuclei may constitute a favorable neuronal environment for the vestibular compensation process. PMID: 21143912
    24. Apoptosis of the retinal neurons in early diabetic rats may correlate with the decline of the activity and mRNA expression of MnSOD. PMID: 20654064
    25. PGC-1alpha is induced by cerebral ischemia leading to upregulation of UCP2 and SOD2, thereby providing a neuroprotective effect against ischemic brain injury in the hippocampus by ameliorating oxidative stress PMID: 19774674
    26. Chronic stress isolation results in mitochondrial dysfunction and MnSOD release into the cytosol. PMID: 19893080
    27. Data highlight the role played by some residues in ratSOD2 and suggest a fine regulation of the enzyme occurring in vivo. PMID: 19384983
    28. MnSod has a role in improving neuronal survival after hypoxia/ischemia PMID: 12577622
    29. Mn-SOD may play a role in regulating ROS and matrix degradation involving mechanical deterioration of the stress-deprived tendon tissue PMID: 15375579
    30. MnSOD is not affected by acute stressors PMID: 16238459
    31. analysis of transcriptional regulation of the superoxide dismutase-2 kappaB element in rat embryonic neurons and astrocytes PMID: 17023425
    32. Experimental abdominal aortic aneurysm formation is associated with early increases in MnSOD expression PMID: 17196988
    33. loss of MnSOD protein contributes to the reduced level of its enzymatic activity and plays a key role in the induction of esophagitis PMID: 17349848
    34. upregulated in neurogenic hypertension PMID: 19047792
    35. both the proportion of SOD2 immunopositive type 1 spiral ganglion cells and the intensity of immunoreactivity were elevated near cochlear apex PMID: 19376215
    36. overexpression in renal proximal tubular cells prevents hyperglycemia-induced changes PMID: 19439219

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  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Iron/manganese superoxide dismutase family
  • 數(shù)據(jù)庫(kù)鏈接：