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  4. Recombinant Saccharomyces cerevisiae Cell division control protein 7 (CDC7), partial

Recombinant Saccharomyces cerevisiae Cell division control protein 7 (CDC7), partial

  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Cell division control protein 7(CDC7) ,partial
  • 貨號：
    CSB-YP356755SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Cell division control protein 7(CDC7) ,partial
  • 貨號：
    CSB-EP356755SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Cell division control protein 7(CDC7) ,partial
  • 貨號：
    CSB-EP356755SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Cell division control protein 7(CDC7) ,partial
  • 貨號：
    CSB-BP356755SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Saccharomyces cerevisiae Cell division control protein 7(CDC7) ,partial
  • 貨號：
    CSB-MP356755SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CDC7; OAF2; YDL017W; D2855Cell division control protein 7; EC 2.7.11.1
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.
  • 基因功能參考文獻(xiàn)：
    1. main conclusion from our studies is that Cdc7 kinase is found at many locations in the genome, but is enriched at functional origins of replication PMID: 29134273
    2. Cdc7 is loosely bound to chromatin during G1. At the G1/S transition, Cdc7 binding to chromatin is increased and stabilized, preferentially at sites that may become replication origins. PMID: 28924058
    3. Data show that Dbf4-dependent kinase (DDK)-phosphoryled MCM DNA helicase complex subunit MCM2 preferentially interacts with DNA replication initiation factor CDC45 PMID: 26305950
    4. Study provides evidence that a key prerequisite for double-strand breaks formation-phosphorylation of Mer2 by Dbf4-dependent Cdc7 kinase, DDK-is linked to replication via association of the kinase with replisome components. PMID: 25126790
    5. *Phosphorylation of Mcm2-7 double hexamers by Dbf4-dependent kinase promotes efficient recruitment of overexpressed firing factors from S-phase extracts. PMID: 24566989
    6. Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. PMID: 23746350
    7. Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits. PMID: 23549044
    8. Inhibition of Cdc7 by the DNA damage response prevents Eco1 destruction, allowing establishment of cohesion after S phase. PMID: 23314252
    9. Cdc7-Dbf4 promotes NDT80 transcription by relieving repression mediated by a complex of Sum1, Rfm1, and a histone deacetylase, Hst1. PMID: 22106412
    10. Studies identify distinct roles for DDK and S-CDK during helicase activation and support a model in which the leading strand DNA polymerase is recruited prior to origin DNA unwinding and RNA primer synthesis. PMID: 21729781
    11. multiple phosphorylation sites within Rec8 as well as two different kinases, casein kinase 1delta/epsilon (CK1delta/epsilon) and Dbf4-dependent Cdc7 kinase (DDK), are required for Rec8 cleavage and meiosis I nuclear division PMID: 20230747
    12. regions on budding yeast Dbf4 required for binding and activating Cdc7 kinase PMID: 19822727
    13. the amino terminal serine/threonine-rich domain (NSD) of Mcm4 has both inhibitory and facilitating roles in DNA replication control and the sole essential function of DDK is to relieve an inhibitory activity residing within the NSD PMID: 20054399
    14. An extensive genetic analysis of the interactions between CDC7 and REV3, RAD30, RAD5, or POL30 in response to DNA damage was done to determine its role in the RAD6 pathway. PMID: 15342501
    15. Cdc7-Dbf4 protein kinase (DDK) promotes assembly of a stable Cdc45-MCM complex exclusively on chromatin in S phase. PMID: 17018296
    16. Cdc7-Dbf4 phosphorylation of the MCM complex normally results in a single, highly active conformation of Mcm5, whereas the mcm5-bob1 mutation produces a number of conformations, only one of which is permissive for origin activation. PMID: 17724082
    17. Coordination between premeiotic S and DSB formation may be achieved by using CDK-S and DDK to initiate both processes. PMID: 18245450
    18. Cdc7, in concert with CDK, regulates Spo11 loading to DSB sites via Mer2 phosphorylation. PMID: 18245451
    19. Cdc7 allows expression of NDT80, is necessary for recruitment of monopolin to sister kinetochores, and it is necessary for the reductional segregation occurring at meiosis I. PMID: 18768747
    20. Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4 PMID: 19013276
    21. incorporation of Mcm2-7 into the prereplicative complex increased the level and changes the specificity of Dbf4-dependent kinase phosphorylation of this complex PMID: 19270162
    22. Cdc7p-Dbf4p prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint. PMID: 19478884
    23. Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth PMID: 19692334

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  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, CDC7 subfamily
  • 數(shù)據(jù)庫鏈接：

    KEGG: sce:YDL017W

    STRING: 4932.YDL017W