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  4. Recombinant Saccharomyces cerevisiae Exosome complex exonuclease RRP6 (RRP6), partial

Recombinant Saccharomyces cerevisiae Exosome complex exonuclease RRP6 (RRP6), partial

  • 中文名稱：
    釀酒酵母RRP6重組蛋白
  • 貨號：
    CSB-YP619566SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母RRP6重組蛋白
  • 貨號：
    CSB-EP619566SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母RRP6重組蛋白
  • 貨號：
    CSB-EP619566SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母RRP6重組蛋白
  • 貨號：
    CSB-BP619566SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母RRP6重組蛋白
  • 貨號：
    CSB-MP619566SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RRP6
  • Uniprot No.：
  • 別名：
    RRP6; UNC733; YOR001W; Exosome complex exonuclease RRP6; EC 3.1.13.-; Ribosomal RNA-processing protein 6
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site.
  • 基因功能參考文獻：
    1. Rrp41 mutations blocked substrate passage through the channel to Rrp44 only for cytoplasmic mRNAs, supporting the predicted widening of the lumen in the Rrp6-associated.Many exosome substrates exhibited clear preferences for a specific path to Rrp44. Both threading and direct access routes involve the RNA helicase Mtr4Rrp41 mutations blocked substrate passage through the channel to Rrp44 only for cytoplasmic mRNAs, suppor PMID: 28355211
    2. Rrp6: Integrated roles in nuclear RNA metabolism and transcription termination PMID: 26612606
    3. The data raise the intriguing possibility that Nab3 and Nrd1 can function independently to recruit Rrp6 to ncRNA targets, providing combinatorial flexibility in RNA processing. PMID: 25775092
    4. The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. PMID: 25319414
    5. Rrp6 acts with the NNS complex(Nrd1, Nab3, and Sen1 ) globally to promote transcription termination in addition to 3' end RNA processing and/or degradation at specific targets. PMID: 25680078
    6. 3.3 A crystal structure of a ten-subunit RNA exosome complex from Saccharomyces cerevisiae composed of the Exo9 core and Rrp6 bound to single-stranded poly(A) RNA PMID: 25043052
    7. Rrp47p reduces the exonucleolytic activity of Rrp6p on both single-stranded and structured RNA substrates without significantly altering the affinity towards RNA or the ability of Rrp6p to degrade RNA secondary structure. PMID: 24937447
    8. results demonstrate that a principal function of Rrp47 is to facilitate appropriate expression levels of Rrp6. PMID: 24224060
    9. In the nucleus of yeast cells, an eleventh component Rrp6 binds to the exosome, providing a second exoribonucleolytic site to the entire complex. PMID: 24189234
    10. Rrp47 and Rrp6 have resolvable functions in Rrp6-mediated RNA surveillance and processing pathways. PMID: 24106327
    11. Assembly of the yeast exoribonuclease Rrp6 with its associated cofactor Rrp47 occurs in the nucleus and is critical for the controlled expression of Rrp47 PMID: 23580640
    12. Rrp6 plays a role in degrading distinct classes of meiotically induced noncoding RNAs during vegetative growth and the onset of meiosis. PMID: 21149693
    13. Rrp6 is required for repair of UV-induced DNA damage PMID: 15489286
    14. the major function of Rrp6p is in RNA surveillance PMID: 16260613
    15. transcripts are somehow distinguished from true mRNAs and are degraded in an Rrp6p-dependent fashion in the nucleus PMID: 16484372
    16. Nab6p binds poly(A)+ RNA, and the functions of Nab6p and Los1p suggest that mRNA metabolism and/or protein synthesis are growth rate limiting in rrp6Delta strains. PMID: 17101774
    17. Results identify a domain within the yeast nucleolus that is enriched in polyadenylated RNAs in the absence of the nuclear exosome RNase Rrp6 or the exosome cofactor Mtr4. PMID: 17403903
    18. Results suggest Rrp47p promotes Rrp6p activity by facilitating binding via the PMC2NT domain to structural elements within RNA. PMID: 17704127
    19. The 3'-5' exonucleolytic domain of Rrp6p is necessary for establishing all quality control phenotypes associated with THO mutations. PMID: 18824516

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  • 亞細胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Exosome component 10/RRP6 family
  • 數據庫鏈接：

    KEGG: sce:YOR001W

    STRING: 4932.YOR001W