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  4. Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein SIN3 (SIN3), partial

Recombinant Saccharomyces cerevisiae Transcriptional regulatory protein SIN3 (SIN3), partial

  • 中文名稱：
    釀酒酵母SIN3重組蛋白
  • 貨號：
    CSB-YP332845SVG
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    釀酒酵母SIN3重組蛋白
  • 貨號：
    CSB-EP332845SVG
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    釀酒酵母SIN3重組蛋白
  • 貨號：
    CSB-EP332845SVG-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母SIN3重組蛋白
  • 貨號：
    CSB-BP332845SVG
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母SIN3重組蛋白
  • 貨號：
    CSB-MP332845SVG
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SIN3
  • Uniprot No.：
  • 別名：
    SIN3; CPE1; GAM2; RPD1; SDI1; SDS16; UME4; YOL004W; Transcriptional regulatory protein SIN3
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalytic component of the RPD3 histone deacetylase complexes RPD3C(L) and RPD3C(S) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. SIN3 has also a RPD3 independent function required for normal longevity.
  • 基因功能參考文獻：
    1. Based on findings, authors conclude that the Tor and PpSin3-PpRpd3 pathway regulates PpAtg32 expression, but not PpAtg32 phosphorylation. PMID: 24838945
    2. These results show that the sin3 mutation decreases both spontaneous and UV-induced levels of levels. PMID: 25711007
    3. investigated the regulatory contribution of subunits of Sin3 complexes and identified Pho23 as important for inositol and choline-dependent gene repression PMID: 22543816
    4. PAH2 and PAH3 od sin3 are required for mitotic early meiotic gene repression. PMID: 20971827
    5. Mutational analysis of the Opi1-Sin3 interaction domain (OSID) revealed that hydrophobic OSID residues L56, V59 and V67 of Opi1 are indispensable for gene repression PMID: 21104417
    6. The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. PMID: 15141165
    7. The Sin3/HDAC complex is involved in an array of biological and cellular processes, including cell cycle progression, genomic stability, embryonic development, and homeostasis. Review. PMID: 19505602
    8. Sin3/Rpd3 histone deacetylase complex helps to prevent premature activation of the S phase in daughter cells. PMID: 19523118

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  • 亞細胞定位：
    Nucleus.
  • 數(shù)據庫鏈接：

    KEGG: sce:YOL004W

    STRING: 4932.YOL004W