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  4. Recombinant Staphylococcus aureus Exfoliative toxin A (eta)

Recombinant Staphylococcus aureus Exfoliative toxin A (eta)

In Stock
  • 中文名稱：
    金黃色釀膿葡萄球菌eta重組蛋白
  • 貨號(hào)：
    CSB-EP357644FKZ
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP357644FKZ could indicate that this peptide derived from E.coli-expressed Staphylococcus aureus eta.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP357644FKZ could indicate that this peptide derived from E.coli-expressed Staphylococcus aureus eta.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    eta
  • Uniprot No.：
  • 別名：
    etaExfoliative toxin A; EC 3.4.21.-; Epidermolytic toxin A
  • 種屬：
    Staphylococcus aureus
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來(lái)源：
    E.coli
  • 分子量：
    30.9kDa
  • 表達(dá)區(qū)域：
    39-280aa
  • 氨基酸序列
    EVSAEEIKKHEEKWNKYYGVNAFNLPKELFSKVDEKDRQKYPYNTIGNVFVKGQTSATGVLIGKNTVLTNRHIAKFANGDPSKVSFRPSINTDDNGNTETPYGEYEVKEILQEPFGAGVDLALIRLKPDQNGVSLGDKISPAKIGTSNDLKDGDKLELIGYPFDHKVNQMHRSEIELTTLSRGLRYYGFTVPGNSGSGIFNSNGELVGIHSSKVSHLDREHQINYGVGIGNYVKRIINEKNE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    The recombinant 6xHis-tagged Staphylococcus aureus Exfoliative toxin A (eta) protein was expressed in E.coli. Amino acid residues Glu39-Glu280 of Staphylococcus aureus eta protein is contained in this recombinant protein. The SDS-PAGE measured its purity of over 90%, and the eta protein migrated to the molecular mass of about 33 kDa on the gel. And It was also validated by the LC-MS/MS analysis. In-stock eta proteins are offered now. This recombinant full-length of mature eta protein may be applied to produce antibodies against eta or in the studies of eta-associated diseases such as staphylococcal scalded skin syndrome (SSSS).

    Eta is a Staphylococcus aureus-expressed exfoliative toxin (ET) that specifically recognizes and hydrolyzes desmoglein 1/Dsg1, a cadherin protein that mediates cell-cell adhesion in keratinocytes. Hydrolysis of Dsg1 destroys epidermal barrier functions and is intrinsically related to physical damage, biochemical degradation, and signaling interruption in the host cells, leading to immune system escape and characterizing pathogen-to-host interactions. As a Staphylococcus aureus virulence factor, Eta is also involved in staphylococcal scalded skin syndrome (SSSS).

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).
  • 蛋白家族：
    Peptidase S1B family