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  4. Recombinant Transitional endoplasmic reticulum ATPase homolog 1 (cdc-48.1), partial

Recombinant Transitional endoplasmic reticulum ATPase homolog 1 (cdc-48.1), partial

  • 中文名稱：
    Recombinant Transitional endoplasmic reticulum ATPase homolog 1(cdc-48.1) ,partial
  • 貨號(hào)：
    CSB-YP345012CXY
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Transitional endoplasmic reticulum ATPase homolog 1(cdc-48.1) ,partial
  • 貨號(hào)：
    CSB-EP345012CXY
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Transitional endoplasmic reticulum ATPase homolog 1(cdc-48.1) ,partial
  • 貨號(hào)：
    CSB-EP345012CXY-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Transitional endoplasmic reticulum ATPase homolog 1(cdc-48.1) ,partial
  • 貨號(hào)：
    CSB-BP345012CXY
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Transitional endoplasmic reticulum ATPase homolog 1(cdc-48.1) ,partial
  • 貨號(hào)：
    CSB-MP345012CXY
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cdc-48.1
  • Uniprot No.：
  • 別名：
    cdc-48.1; C06A1.1Transitional endoplasmic reticulum ATPase homolog 1; EC 3.6.4.6; Cell division cycle-related protein 48.1; p97/CDC48 homolog 1
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. In association with helicase him-6 and GTPase crp-1, regulates the unfolded protein response (UPR) following ER stress, probably independently of the ERAD pathway. Together with udf-2 and chn-1, regulates myosin assembly in body wall muscles by targeting myosin chaperone unc-45 for proteasomal degradation. Together with the ufd-1-npl-4 complex, controls the switch from spermatogenesis to oogenesis by regulating E3 ligase cul-2 complex-mediated tra-1 proteasomal degradation. During oocyte meiosis and together with cdc-48.2, required for chromosome condensation at the diakinesis phase in prophase I and for progression of metaphase I. During the first embryonic cell division, regulates DNA replication and thus chromosome segregation and decondensation, and nuclear envelope re-assembly. In S phase and in association with ufd-1, npl-4.1 and/or npl-4.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5. Regulates ubxn-3 nuclear localization during S phase. During the first embryonic cell divisions and together with cdc-48.2, regulates the re-assembly of the nuclear envelope after mitosis possibly by inactivating kinase air-2, a component of the chromosomal passenger complex (CPC). However, in another study, cdc-48.1 does not appear to be implicated in the regulation of air-2.
  • 基因功能參考文獻(xiàn)：
    1. A novel role for p97/CDC-48, whereby its role in protein degradation is integrated with its role in regulating expression of endoplasmic reticulum stress response genes. PMID: 25652260
    2. In the presence of ATP, the N-D1 ring repeatedly rotates 23 degrees clockwise and resets relative to the D2 ring. PMID: 24055316
    3. All six UBXN proteins directly interacted with CDC-48.1, and simultaneous knockdown of the expression of three genes, ubxn-1, ubxn-2 and ubxn-3, induced embryonic lethal and sterile phenotypes, but knockdown of either one or two did not. PMID: 20977550
    4. Positive cooperativity of the p97 AAA ATPase is critical for essential functions. PMID: 21454554
    5. The C. elegans p97/CDC-48-UFD-1-NPL-4 complex controls the sperm-oocyte switch by regulating CUL-2-mediated TRA-1A proteasome degradation. PMID: 19773360
    6. C. elegans p97 plays an important role in the progression of meiosis PMID: 17512499
    7. A novel signaling module involving CRP-1 and CDC-48 which may directly link the unfolded protein response to DNA remodeling and transcription control. PMID: 18458060

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  • 亞細(xì)胞定位：
    Cytoplasm, perinuclear region. Cytoplasm.
  • 蛋白家族：
    AAA ATPase family, CDC48 subfamily
  • 組織特異性：
    Expressed in germ cells and spermatheca. Expressed in body wall muscles.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: cel:CELE_C06A1.1

    STRING: 6239.C06A1.1.2

    UniGene: Cel.17764