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  4. Recombinant Drosophila melanogaster Protein rhomboid (rho)

Recombinant Drosophila melanogaster Protein rhomboid (rho)

  • 中文名稱：
    黑腹果蠅rho重組蛋白
  • 貨號：
    CSB-CF323222DLU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    rho; Ve; CG1004; Protein rhomboid; Protein veinlet
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-355
  • 氨基酸序列
    MENLTQNVNETKVDLGQEKEKEASQEEEHATAAKETIIDIPAACSSSSNSSSYDTDCSTA SSTCCTRQGEHIYMQREAIPATPLPESEDIGLLKYVHRQHWPWFILVISIIEIAIFAYDR YTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPL EVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMKS ASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFG HREYEQLIWWLALGVYCAFTVFAIVFNLINTVTAQLMEEQGEVITQHLLHDLGVS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor.
  • 基因功能參考文獻：
    1. a rhomboid enhancer element that selectively labels four Drosophila embryonic neural precursors, was characterized. PMID: 26252385
    2. Structure and mechanism of rhomboid protease. PMID: 23585569
    3. analysis of EGFR-dependent network interactions that pattern Drosophila eggshell appendages; each appendage is derived from a primordium comprising a patch of cells expressing broad (br) and an adjacent stripe of cells expressing rhomboid (rho) PMID: 22782725
    4. Drosophila RHO is the founder member of a previously undescribed family of serine proteases, and could be directly responsible for the unusual, intramembranous cleavage of EGFr ligands. PMID: 12221285
    5. A key component of mitochondrial fusion, Mgm1p, is activated by a novel mitochondrial endopeptidase related to this Drosophila melanogaster signaling protein. PMID: 12776123
    6. Substrate specificity of RHO intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
    7. Evolution of the trans-regulatory environment that controls rho expression in somatic follicle cells could be a major contributor to the evolutionary changes in DA number. PMID: 17360774
    8. rhomboid may function in R8 cells to activate Epidermal growth factor receptor signaling in R7 cells PMID: 19261861

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  • 亞細胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase S54 family
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG1004

    STRING: 7227.FBpp0305409

    UniGene: Dm.808