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  4. Recombinant Human Brain protein I3 (BRI3)

Recombinant Human Brain protein I3 (BRI3)

  • 中文名稱：
    Recombinant Human Brain protein I3(BRI3)
  • 貨號：
    CSB-CF002811HU
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    BRI3
  • Uniprot No.：
  • 別名：
    BRI3; Brain protein I3; pRGR2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-125
  • 氨基酸序列
    MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIH SRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNC GATFA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver.
  • 基因功能參考文獻(xiàn)：
    1. In the context of hepatocellular carcinoma cells, BRI3 is a target of WNT signaling. PMID: 20538055
    2. An X-ray data set was collected to 1.6 A resolution using synchrotron radiation, of a ligandin recombinant fusion protein. PMID: 16508092
    3. Possible roles of BRI3 in the process of neuronal differentiation. PMID: 18452648
    4. BRI3 inhibits the various processing of amyloid protein precursor by blocking the access of alpha- and beta-secretases. PMID: 19366692
    5. BRI3 RNA is expressed less in stage 3 colon cancer in comparison to stage 2 colon cancer, and it is among 8 genes which can be used as a gene signature to differentiate colon cancer stages. PMID: 17390049

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  • 亞細(xì)胞定位：
    Lysosome membrane; Multi-pass membrane protein.; [Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    BRI3 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1109

    OMIM: 615628

    KEGG: hsa:25798

    STRING: 9606.ENSP00000297290

    UniGene: Hs.567438