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Recombinant Meleagris gallopavo Beta-1 adrenergic receptor (ADRB1)

  • 中文名稱：
    Recombinant Meleagris gallopavo Beta-1 adrenergic receptor(ADRB1)
  • 貨號(hào)：
    CSB-CF001391MQV
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    ADRB1; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor; Beta-T
  • 種屬：
    Meleagris gallopavo (Common turkey)
  • 蛋白長(zhǎng)度：
    full length protein
  • 表達(dá)區(qū)域：
    1-483
  • 氨基酸序列
    MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNV LVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSL DVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMH WWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRK IDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFT LCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFP RKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRS ESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQ HQA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. In dorsal pons neurons, involved in the regulation of sleep/wake behaviors.
  • 基因功能參考文獻(xiàn)：
    1. In both sexes of Crollwitzer turkey hearts, the beta1-AR density decreased with age but significance was reached in male cardiac chambers. PMID: 29253207
    2. backbone NMR reveals allosteric signal transduction networks in the beta1-adrenergic receptor PMID: 26840483
    3. 2.1 A resolution structure of cyanopindolol-bound beta1-adrenoceptor identifies an intramembrane Na+ ion that stabilises the ligand-free receptor PMID: 24663151
    4. Monoclonal anti-beta1-adrenergic receptor antibodies activate G protein signaling in the absence of beta-arrestin recruitment PMID: 24253107
    5. Although the combination of mutations severely reduced the activation ability of ADRB1, the final crystallised receptor (beta36-m23) was still a functional receptor capable of binding agonists and antagonists and activating cellular agonist responses. PMID: 21547538
    6. 2.7 A resolution crystal structure of turkey beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol PMID: 18594507
    7. Molecular simulations of beta-1 AR show formation of an ionic lock, with the cytoplasmatic end of transmembrane (TM)6 helix approaching TM3 resulting in an equilibrium geometry that is stabilized by direct interaction of arginine and glutamate. PMID: 19378975
    8. The all-atom force-field energy function was used to calculate a stability score to detect stabilizing point mutations in G-protein coupled receptors. PMID: 20643076
    9. four crystal structures of the thermostabilized turkey beta(1)-adrenergic receptor bound to the full agonists carmoterol and isoprenaline and the partial agonists salbutamol and dobutamine PMID: 21228877

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Early endosome.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB1 sub-subfamily
  • 數(shù)據(jù)庫(kù)鏈接：