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  4. Recombinant Mouse Probable G-protein coupled receptor 88 (Gpr88)

Recombinant Mouse Probable G-protein coupled receptor 88 (Gpr88)

  • 中文名稱：
    小鼠Gpr88重組蛋白
  • 貨號：
    CSB-CF887640MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Gpr88; Strg; Probable G-protein coupled receptor 88; Striatum-specific G-protein coupled receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-384
  • 氨基酸序列
    MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFR KLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPSGSAEPPGDWDGGGGSYRLLRGGLL GLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTVGMLALSWALALGLVLLLPPWA PKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGC AAAAAAFPAAPHAPGPGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPL VWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAA AAAATAVPAMSQAQLGTRAAGQHW
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.
  • 基因功能參考文獻：
    1. GPR88 in A2A receptor-expressing neurons modulates psychomotor behavior but not sensorimotor gating. PMID: 28700108
    2. GPR88 activity shapes the mouse brain functional and structural connectome PMID: 28882062
    3. Analysis of Gpr88-adenosine A2AR-Cre transgenic mice shows that GPR88 in adenosine A2AR medium spiny neurons regulates locomotor and anxiety behaviors. PMID: 27570825
    4. GPR88 expression in the corpus striatum is necessary to efficiently integrate effort and choice behavior. PMID: 28729439
    5. Results demonstrate that GPR88 is implicated in a large repertoire of behavioral responses that engage motor activity, spatial learning, and emotional processing, reveal functional antagonism between GPR88 and delta opioid receptor activities in vivo PMID: 26188600
    6. This study demonistrated that lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors PMID: 23064379
    7. The modulatory role of Gpr88 in striatal dopamine function suggests it may be a new target for treatments for psychiatric disorders. PMID: 19796684

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Nucleus.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Expressed predominantly in the striatum.
  • 數(shù)據(jù)庫鏈接：