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  4. Recombinant Mouse Steryl-sulfatase (Sts)

Recombinant Mouse Steryl-sulfatase (Sts)

  • 中文名稱：
    小鼠Sts重組蛋白
  • 貨號(hào)：
    CSB-CF022883MO
  • 規(guī)格：
  • 來(lái)源：
    in vitro E.coli expression system
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Sts
  • Uniprot No.：
  • 別名：
    Sts; Steryl-sulfatase; Arylsulfatase C; ASC; Steroid sulfatase; Steryl-sulfate sulfohydrolase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    23-624
  • 氨基酸序列
    ADPAPAGPAPRPPNFLLIMADDLGIGDLGCYGNKTLRTPHLDRLAREGVKLTQHLAAAPL CTPSRAAFLTGRYPPRSGMAAHGRVGVYLFTASSGGLPPSEVTMARLLKGRGYATALIGK WHLGLSCRGATDFCHHPLRHGFDRFLGVPTTNLRDCRPGAGTVFGPALRVFAAGPLAALG ASLAAMAAARWAGLARVPGWALAGTAAAMLAVGGPRSASCLGFRPANCFLMDDLAVAQRP TDYGGLTRRLADEAALFLRRNRARPFLLFLSFLHVHTAHFADPGFAGRSLHGAYGDSVEE MDWGVGRVLAALDELGLARETLVYFTSDHGAHVEELGPRGERMGGSNGVFRGGKGNNWEG GVRVPCLVRWPRELSPGRVVAEPTSLMDVFPTVARLAGAELPGDRVIDGRDLMPLLRGDA QRSEHEFLFHYCNAYLQAVRWHNGSAVWKAFYFTPNFAPAGANGCFSTHVCLCAGPAHVT AHDPPLLFDLTRDPGERRPLTPEAEPRHREVLDAIDAAARAHRARLRPAPDQLAPRHLMW KPWLQLWGGGGAGGGAGAQDDSGHAHGDGSHAHDDPGHAQDRGDDDAHYGGHATTRTQAT PR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of STS in the liver improved metabolic functions in mouse models of obesity and type 2 diabetes through sex-specific mechanisms. PMID: 24497646
    2. These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system. PMID: 22189290
    3. steroid sulfatase may influence core and associated ADHD behavioural endophenotypes via both developmental and ongoing mechanisms, and that the 39,X(Y*)O model may represent a useful tool for elucidating the neurobiological basis of these endophenotypes. PMID: 21723668
    4. analysis of brain pathways mediating the pro-aggressive effect of the steroid sulfatase (Sts) gene PMID: 20155394
    5. Our data suggest that variation within STS may be particularly associated with the inattentive subtype of ADHD PMID: 19251250

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  • 亞細(xì)胞定位：
    Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The sequence shows several membrane-spanning domains that could serve to anchor the protein in the microsomal membrane.
  • 蛋白家族：
    Sulfatase family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:20905

    UniGene: Mm.423011