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  4. Recombinant Mouse T-cell surface antigen CD2 (Cd2)

Recombinant Mouse T-cell surface antigen CD2 (Cd2)

  • 中文名稱：
    Recombinant Mouse T-cell surface antigen CD2(Cd2)
  • 貨號：
    CSB-CF004894MO
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Cd2; Ly-37; T-cell surface antigen CD2; LFA-2; LFA-3 receptor; Lymphocyte antigen 37; T-cell surface antigen T11/Leu-5; CD antigen CD2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    23-344
  • 氨基酸序列
    RDNETIWGVLGHGITLNIPNFQMTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVMVYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLNSLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLVLLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAPPPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGSGDGVSLPPPN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
  • 基因功能參考文獻：
    1. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes PMID: 26438525
    2. CD2 stimuli were mandatory for Treg cell survival with reduced Bim expression, but CD2 may not function as a direct receptor for molecules on stromal cells. PMID: 23278598
    3. CD2 is important for the efficient development of CD4 single-positive thymocytes and TCR-dependent activation of mature CD4 lymph node T cells, but does not direct a particular helper T cell subset polarity. PMID: 11801645
    4. This antigen is a dominant target for heart allograft responses. PMID: 12201362
    5. molecular mechanism of heterophilic adhesion between the murine T-cell adhesion glycoprotein CD2 and its ligand CD48 PMID: 12356317
    6. Despite normal T cell numbers, mice deficient in the costimulatory molecules CD2 and CD28 spontaneously develop Pneumocystis carinii pneumonia. PMID: 12902500
    7. autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster PMID: 15589166
    8. Analysis of the ligand-receptor pairs involved in induction of germline transcripts (Igamma2a) necessary for switch recombination revealed that expression of CD48 on B cells and ligands CD2 and CD244 on NK cells are able to stimulate Igamma2a PMID: 15778370
    9. CD2 deficient mice are more resistant to T. gondii infection than wild type mice PMID: 17696249
    10. nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse PMID: 18826951
    11. CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1 PMID: 19586919

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in thymus and spleen.
  • 數(shù)據庫鏈接：