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  4. Recombinant Rat Melanin-concentrating hormone receptor 1 (Mchr1)

Recombinant Rat Melanin-concentrating hormone receptor 1 (Mchr1)

  • 中文名稱：
    大鼠Mchr1重組蛋白
  • 貨號：
    CSB-CF013584RA
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Mchr1; Gpr24; Slc1; Melanin-concentrating hormone receptor 1; MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-360
  • 氨基酸序列
    QATCTGCMDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLL GIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGE TMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFI SITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQ RMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLY NAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for melanin-concentrating hormone, coupled to G proteins that inhibit adenylyl cyclase.
  • 基因功能參考文獻：
    1. data suggest a dual role of MCH and the MCH1-R in regulation of alcohol intake, possibly through mechanisms involving caloric intake and reward motivation. PMID: 27579857
    2. MCH levels in the CSF, brain preproMCH and MCHR1 gene expression during paradoxical sleep deprivation, sleep rebound and chronic sleep restriction were studied in rats. PMID: 26456505
    3. The study identified the amino acids that are selectively involved in Gi/o activation by rat melanin-concentrating hormone receptor 1. PMID: 25617691
    4. Data indicate that Mch/Mchr1 signal transduction participates in modulation of depression-like behavior through processes in CA1 region of hippocampus. Model of depression involves chronically higher Mch expression and down-regulation of Mchr1. PMID: 22209364
    5. Diet-induced obesity and related metabolic disorders are possibly correlated with up-regulated expression of MCHR1 and down-regulated expression of OB-Rb in adipose tissue. PMID: 21946196
    6. Data suggest that MCH and its receptor (MCHR1) form an orexigenic system whose expression is affected in conditioned taste aversion. MCHR1 expression is up-regulated in hypothalamus and brain stem (and possibly amygdala) of aversive animals. PMID: 21925200
    7. The basic residues in the membrane-proximal C-terminal tail of the rat melanin-concentrating hormone receptor 1 are required for receptor function. PMID: 15117878
    8. MCH1R undergoes rapid melanin concentating hormone-induced internalization and that a portion of the C-terminal tail plays an important role in the internalization process. PMID: 15476926
    9. Periplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail PMID: 15590649
    10. Castration and testosterone treatment on the vasculature in the ventral prostate in adult rats and mice alter expression of this protein. PMID: 15845622
    11. These data support the notion that MIZIP might interact with elanin-concentrating hormone receptor 1 (MCHR1) in a cell type specific manner in vivo, suggesting a role in the regulation of MCH signalling in distinct regions of the mammalian brain. PMID: 15950311
    12. In nodose ganglia from rats fasted for 24 h, RT-PCR revealed the expression of both melanin-concentrating hormone and MCHR1, whereas in nodose ganglia from animals fed ad libitum expression was virtually undetectable. PMID: 16359819
    13. the results support a role of the melanin-concentrating hormone MCH(1) receptor in the regulation of deep slow-wave sleep-REM sleep cycle PMID: 18062961
    14. RGS8, which is highly expressed in the brain, functions as a negative modulator of MCH1R signaling. PMID: 18760349
    15. SNAP79441 inhibitis this receptor and reduces the micturition response in rats. PMID: 18849359
    16. data suggest that the major contribution of the DRY motif in MCH1R is to govern receptor conformation and G protein coupling/recognition PMID: 19428776

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    High level in the brain, moderate amounts in the eye and skeletal muscle, and small amounts in tongue and pituitary.
  • 數(shù)據(jù)庫鏈接：