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  4. Recombinant Rat Small conductance calcium-activated potassium channel protein 2 (Kcnn2)-VLPs

Recombinant Rat Small conductance calcium-activated potassium channel protein 2 (Kcnn2)-VLPs

  • 中文名稱：
    Recombinant Rat Small conductance calcium-activated potassium channel protein 2 (Kcnn2)-VLPs
  • 貨號：
    CSB-MP012084RA
  • 規(guī)格：
  • 其他：

產(chǎn)品詳情

  • 基因名：
    Kcnn2
  • Uniprot No.：
  • 別名：
    (SK2)(SKCa 2)(SKCa2)(KCa2.2)
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length
  • 來源：
    Mammalian cell
  • 表達區(qū)域：
    1-580aa
  • 氨基酸序列
    MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS-
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項：
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
  • 基因功能參考文獻：
    1. Study characterized and genetically analyzed F344-Trdk/+ rats. Tremor behaviors were suppressed by anti-tremor agents for essential tremor, but not for Parkinson's disease. A missense mutation, I289N, was detected in the Kcnn2 gene of F344-Trdk/+ rats. Electrophysiological studies in HEK293 cells revealed that this mutation diminished KCNN2 channel function. PMID: 28917524
    2. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. PMID: 28282037
    3. EDH-mediated responses are impaired in superior mesenteric arteries of SHRSP because of a reduction in both TRPV4 and SKCa input to EDH. PMID: 27872234
    4. Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2. PMID: 26362340
    5. Sarcoplasmic reticulum Ca(2+) release is both necessary and sufficient for the activation of SK channels in rat ventricular myocytes. PMID: 24381116
    6. SK2 and SK3 channels are expressed in different populations of motoneurons in rats and mice but not in cats PMID: 23129791
    7. SK2 channels are expressed in rat cerebellar Purkinje cells during development and throughout adulthood PMID: 21521760
    8. Allosteric block of KCa2 channels by apamin. PMID: 20562108
    9. SK2 is expressed in inner hair cells during postnatal weeks 1-2. It is downregulated after the onset of hearing. PMID: 15356192
    10. In the intact SK channel complex, the N-lobe of calmodulin provides ligand-binding sites for channel gating, and that its ligand-binding properties are comparable to those of the N-lobe in isolated calmodulin. PMID: 19144926

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Potassium channel KCNN family, KCa2.2/KCNN2 subfamily
  • 組織特異性：
    Brain.
  • 數(shù)據(jù)庫鏈接：