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  4. Recombinant Sheep Adrenocorticotropic hormone receptor (MC2R)

Recombinant Sheep Adrenocorticotropic hormone receptor (MC2R)

  • 中文名稱：
    綿羊MC2R重組蛋白
  • 貨號：
    CSB-CF890597SH
  • 規(guī)格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    MC2R; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R
  • 種屬：
    Ovis aries (Sheep)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-295
  • 氨基酸序列
    MRHILNLYENINSTARNNSDCPAVILPEEIFFTVSIVGVLENLMVLLAVAKNKSLQSPMY FFICSLAISDMLGSLYKILENVLIMFRNMGYLEPRGSFESTADDVVDSLFILSLLGSICS LSVIAADRYITIFHALQYHSIVTMHRALVVLTVLWAGCTGSGITIVTFSHHVPTVIAFTA LFPLMLAFILCLYVHMFLLARSHARRTSSLPKANMRGAITLTVLLGVFIFCWAPFVLHVL LMTFCPADPYCACYMSLFQVNGVLIMCNAVIDPFIYAFRSPELRVAFKKMVICNW
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).
  • 基因功能參考文獻：
    1. data show that the ovine placenta expresses steroidogenic acute regulatory protein (StAR) and adrenocorticotropic hormone receptor (ACTH-R) but there were no significant age-related changes in ACTH-R mRNA and protein levels PMID: 15193873
    2. Absence of the cortisol surge in hypothalamic-pituitary disconnection fetuses is a consequence, at least in part, of decreased ACTH receptor expression and adrenal responsiveness. PMID: 15802563
    3. data suggest that ACTH receptor and StAR are key mediators of fetal adrenocortical responsiveness, and that ACTH is able to up-regulate responsiveness, and hence cortisol production, by increasing their expression PMID: 15979353
    4. These findings demonstrate that increases in circulating ACTH levels promote increased expression of ACTH-R and StAR mRNA and are coupled to heightened adrenal responsiveness. PMID: 16478774
    5. Suggest that upregulation of the ACTH-R expression in late gestation is essential for the increase in adrenal steroidogenic capacity occurring then. PMID: 18421020

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    KEGG: oas:443482

    UniGene: Oar.711