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ALOX5

ALOX5,即花生四烯酸5-脂氧合酶,別名Arachidonate 5-lipoxygenase。它屬于脂氧合酶家族成員,由人體細(xì)胞自身編碼產(chǎn)生。ALOX5在多種細(xì)胞類(lèi)型中都有表達(dá),特別是在骨髓衍生的細(xì)胞中表達(dá)量較高。其作用機(jī)制主要是催化花生四烯酸轉(zhuǎn)化為5(S)-HPETE,進(jìn)而生成白三烯A4(LTA4),這是白三烯生物合成途徑中的起始和關(guān)鍵步驟。白三烯是一類(lèi)重要的炎癥介質(zhì),參與多種炎癥和過(guò)敏反應(yīng)的調(diào)控。ALOX5的活性受到多種因素的調(diào)控,包括細(xì)胞因子、應(yīng)激反應(yīng)和細(xì)胞內(nèi)信號(hào)分子等。ALOX5在生物學(xué)上的意義主要體現(xiàn)在其對(duì)炎癥反應(yīng)的調(diào)控作用。它不僅參與了白三烯的合成,影響炎癥和免疫過(guò)程,還可能參與脂質(zhì)過(guò)氧化和細(xì)胞死亡模式的調(diào)控,如凋亡、焦亡和鐵死亡。ALOX5的表達(dá)或活性異常與多種疾病的發(fā)生發(fā)展有關(guān),包括哮喘、動(dòng)脈粥樣硬化、腫瘤等。此外,ALOX5還可能作為腫瘤免疫微環(huán)境中的一個(gè)重要因素,影響腫瘤的免疫細(xì)胞浸潤(rùn)和免疫治療的效果,因此,它也是藥物開(kāi)發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) (CSB-CF001625HU)

驗(yàn)證數(shù)據(jù)

CSB-CF001625HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALOX5 Recombinant Monoclonal Antibody (CSB-RA198316A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA198316A0HU

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA198316A0HU

IHC image of CSB-RA198316A0HU diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ALOX5 Antibodies

ALOX5 for Homo sapiens (Human)

ALOX5 Proteins

ALOX5 Proteins for Rattus norvegicus (Rat)

ALOX5 Proteins for Mus musculus (Mouse)

ALOX5 Proteins for Homo sapiens (Human)

ALOX5 Proteins for Mesocricetus auratus (Golden hamster)

ALOX5 ELISA Kit

ALOX5 ELISA Kit for Rattus norvegicus (Rat)