A33R
A33R，即抗原33相關(guān)蛋白，別名CD227、TACSTD2等。該蛋白是由TACSTD2基因編碼的一種跨膜糖蛋白，主要在上皮細(xì)胞表面表達(dá)。A33R最初因在結(jié)直腸癌中的高表達(dá)而被識(shí)別，現(xiàn)已被證實(shí)廣泛存在于多種上皮性腫瘤中，如乳腺癌、卵巢癌等。其生物學(xué)功能多樣，主要包括促進(jìn)細(xì)胞間的黏附，維持上皮組織的結(jié)構(gòu)完整性和細(xì)胞極性。此外，A33R還參與調(diào)控細(xì)胞增殖、分化及信號(hào)傳導(dǎo)，尤其是與Wnt/β-catenin信號(hào)通路的交互作用，對(duì)腫瘤的發(fā)生發(fā)展有著重要影響。通過與特定配體或細(xì)胞表面分子的相互作用，A33R能激活下游信號(hào)通路，影響細(xì)胞周期和凋亡過程。鑒于其在腫瘤細(xì)胞上的特異性高表達(dá)，A33R成為了癌癥早期診斷、預(yù)后評(píng)估及靶向治療的重要標(biāo)志物和潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Vaccinia virus Protein A33 (A33R), partial (CSB-EP300755VAA1b0)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
A33R Antibody (CSB-PA300755ZA01VAA)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: recombinant protein
All lanes:A33R Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 23 kDa
Observed band size: 23 kDa
A33R Antibodies
A33R for Vaccinia virus (strain Copenhagen) (VACV)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA300755ZA01VAA | A33R Antibody | Vaccinia virus (strain Copenhagen) (VACV) | ELISA, WB |
A33R Proteins
A33R Proteins for Vaccinia virus (strain Copenhagen) (VACV)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP300755VAA1 | Recombinant Vaccinia virus Protein A33 (A33R), partial | Yeast |
| CSB-CF300755VAA | Recombinant Vaccinia virus Protein A33 (A33R) | in vitro E.coli expression system |
| CSB-EP300755VAA1 | Recombinant Vaccinia virus Protein A33 (A33R), partial | E.coli |
| CSB-BP300755VAA1 | Recombinant Vaccinia virus Protein A33 (A33R), partial | Baculovirus |
| CSB-MP300755VAA1 CSB-EP300755VAA1-B |
Recombinant Vaccinia virus Protein A33 (A33R), partial | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP300755VAA1b0 | Recombinant Vaccinia virus Protein A33 (A33R), partial | E.coli |
