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AARS1

AARS1,即丙氨酰-tRNA合成酶1,別名AARS、TTD8、CMT2N、DEE29、HDLS2、EIEE29。它是由人類細(xì)胞中的AARS1基因編碼的一種蛋白質(zhì)。AARS1在細(xì)胞質(zhì)中發(fā)揮作用,主要負(fù)責(zé)將丙氨酸(一種氨基酸)連接到其相應(yīng)的tRNA上,這一過程稱為氨?;堑鞍踪|(zhì)合成的關(guān)鍵步驟。此外,AARS1還具有乳酸傳感器和乳酰轉(zhuǎn)移酶的功能,能夠乳酸化修飾p53蛋白,影響其抑癌功能,從而促進(jìn)腫瘤發(fā)生。AARS1不僅在蛋白質(zhì)合成中發(fā)揮重要作用,還參與調(diào)控細(xì)胞代謝和腫瘤發(fā)展。AARS1的異常表達(dá)或突變與多種疾病相關(guān),包括神經(jīng)病變和某些類型的癌癥。

熱銷產(chǎn)品

AARS Antibody (CSB-PA001023LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA001023LA01HU

IHC image of CSB-PA001023LA01HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA001023LA01HU

IHC image of CSB-PA001023LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA001023LA01HU

Immunofluorescence staining of Hela cells with CSB-PA001023LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

AARS1 Antibodies

AARS1 for Homo sapiens (Human)

AARS1 Proteins

AARS1 Proteins for Homo sapiens (Human)