ADA

ADA，即腺苷脫氨酶，是一種參與嘌呤代謝途徑的關(guān)鍵酶（EC3.5.4.4）。它在人體中的主要功能是免疫系統(tǒng)的發(fā)育和維持，尤其在淋巴細(xì)胞和巨噬細(xì)胞中發(fā)揮作用。ADA的作用機(jī)制包括不可逆地催化腺苷脫去氨基，轉(zhuǎn)化為肌苷，然后肌苷可進(jìn)一步被嘌呤核苷磷酸化酶（PNP）轉(zhuǎn)化為次黃嘌呤。ADA活性位點含有鋅離子，該離子是ADA活性所必需的唯一輔助因子，底物腺苷通過多個氫鍵與活性位點結(jié)合并被催化。ADA在信號傳導(dǎo)中的作用涉及到調(diào)節(jié)細(xì)胞內(nèi)腺苷水平，腺苷是一種強(qiáng)效的免疫調(diào)節(jié)分子，通過其受體影響細(xì)胞功能。ADA的活性還與多種生理和病理過程相關(guān)，包括上皮細(xì)胞分化、神經(jīng)傳遞以及妊娠維持等。在生物學(xué)意義上，ADA不僅在嘌呤補(bǔ)救途徑中發(fā)揮關(guān)鍵作用，而且其活性的變化與多種疾病相關(guān)，例如ADA缺乏可導(dǎo)致嚴(yán)重聯(lián)合免疫缺陷（SCID），而ADA活性的增加與某些癌癥、自身免疫疾病以及HIV/AIDS有關(guān)。因此，ADA是免疫調(diào)節(jié)和疾病診斷中的一個重要生物標(biāo)志物。

熱銷產(chǎn)品

ADA Antibody (CSB-PA240615)

驗證數(shù)據(jù)

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA240615(ADA Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA240615(ADA Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Raji cells, Primary antibody: CSB-PA240615(ADA Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

Human adenosine deaminase,ADA ELISA Kit (CSB-E09613h)

驗證數(shù)據(jù)

貨號：CSB-E09613h

規(guī)格：96T/48T

靈敏度：0.39 mIU/mL

檢測范圍：1.56 mIU/mL-100 mIU/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ADA Antibody

ADA Protein

ADA ELISA Kit

ADA Antibodies

ADA for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA001268EA01HU	ADA Antibody	Human	ELISA, WB, IHC, IF
CSB-PA001268EB01HU	ADA Antibody, HRP conjugated	Human	ELISA
CSB-PA240615	ADA Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA776767	ADA Antibody	Human,Mouse,Rat	ELISA,WB,IHC

ADA Proteins

ADA Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP001268HU CSB-EP001268HU CSB-BP001268HU CSB-MP001268HU CSB-EP001268HU-B	Recombinant Human Adenosine deaminase (ADA)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli