ADAMTS4

ADAMTS4蛋白全稱為整合素樣金屬蛋白酶與血小板反應(yīng)蛋白基序4，常被稱為Aggrecanase-1或ADMP-1。該蛋白在維持細(xì)胞外基質(zhì)動(dòng)態(tài)平衡中起關(guān)鍵作用，能夠特異性分解軟骨組織中的核心成分aggrecan，這種特性使其成為關(guān)節(jié)退行性疾病的重要研究靶點(diǎn)。在骨關(guān)節(jié)炎和類風(fēng)濕性關(guān)節(jié)炎患者體內(nèi)，其異?；钴S的酶切活性會(huì)加速軟骨基質(zhì)破壞，導(dǎo)致關(guān)節(jié)結(jié)構(gòu)塌陷和功能喪失。ADAMTS4在腫瘤微環(huán)境中同樣扮演著特殊角色，可能通過重塑細(xì)胞外基質(zhì)促進(jìn)癌細(xì)胞侵襲轉(zhuǎn)移，特別是在乳腺癌和膠質(zhì)瘤中觀察到其表達(dá)水平與疾病進(jìn)展密切相關(guān)。
針對(duì)ADAMTS4的藥物開發(fā)主要聚焦于選擇性抑制劑研究，已有多個(gè)小分子化合物進(jìn)入臨床前試驗(yàn)階段，通過阻斷其酶活性來減緩軟骨退化進(jìn)程。其中部分黃酮類衍生物在動(dòng)物模型中顯示出保護(hù)關(guān)節(jié)軟骨的效果，而基于單克隆抗體的靶向療法也取得突破性進(jìn)展。值得關(guān)注的是，某些已上市的抗炎藥物被發(fā)現(xiàn)具有間接調(diào)控該蛋白活性的潛能，這為老藥新用開辟了新方向。目前相關(guān)研究正在探索其在神經(jīng)退行性疾病中的應(yīng)用價(jià)值，特別是阿爾茨海默病中淀粉樣斑塊的形成可能與ADAMTS4介導(dǎo)的蛋白水解過程存在關(guān)聯(lián)。

熱銷產(chǎn)品

Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), partial (CSB-EP001311HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ADAMTS4 Antibody (CSB-PA001311LA01HU)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001311LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: Mouse kidney tissue
All lanes: ADAMTS4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 91 kDa
Observed band size: 91 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001311LA01HU at dilution of 1:100

IHC image of CSB-PA001311LA01HU diluted at 1:250 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human ADAM metallopeptidase with thrombospondin type 1 motif4,ADAMTS4 ELISA Kit (CSB-E11848h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E11848h

規(guī)格：96T/48T

靈敏度：3.125 ng/ml

檢測(cè)范圍：12.5 ng/ml - 800 ng/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ADAMTS4 Antibody

ADAMTS4 Protein

ADAMTS4 ELISA Kit

ADAMTS4 Antibodies

ADAMTS4 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA001311LA01HU	ADAMTS4 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA001311LB01HU	ADAMTS4 Antibody, HRP conjugated	Human	ELISA
CSB-PA001311LC01HU	ADAMTS4 Antibody, FITC conjugated	Human
CSB-PA001311LD01HU	ADAMTS4 Antibody, Biotin conjugated	Human	ELISA

ADAMTS4 Proteins

ADAMTS4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP001311HU CSB-EP001311HU CSB-BP001311HU CSB-MP001311HU CSB-EP001311HU-B	Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001311HU1	Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4), partial	E.coli