ADAMTS5

ADAMTS5全稱為ADAM金屬肽酶含血小板反應蛋白1型基序5，也被稱為聚集蛋白聚糖酶-2。該蛋白在細胞外基質(zhì)代謝中扮演關鍵角色，主要通過分解聚集蛋白聚糖這類維持軟骨彈性的核心成分，影響關節(jié)組織的穩(wěn)定性。ADAMTS5活性異常升高與軟骨退化密切相關，尤其在骨關節(jié)炎患者關節(jié)液中可檢測到顯著升高的酶活性水平。此外，該蛋白還參與調(diào)控炎癥因子釋放，間接加速關節(jié)腔微環(huán)境失衡。目前針對ADAMTS5的抑制劑開發(fā)成為骨關節(jié)炎治療的重要方向，例如單克隆抗體和小分子化合物已進入臨床試驗階段，旨在阻斷其對軟骨基質(zhì)的過度破壞。近期研究還發(fā)現(xiàn)ADAMTS5可能與其他纖維化疾病及腫瘤轉(zhuǎn)移存在關聯(lián)，但其具體作用路徑仍在探索中。

熱銷產(chǎn)品

ADAMTS5 Antibody (CSB-PA890943LA01HU)

驗證數(shù)據(jù)

IHC image of CSB-PA890943LA01HU diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human A disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5) ELISA kit (CSB-EL001312HU)

驗證數(shù)據(jù)

貨號：CSB-EL001312HU

規(guī)格：96T/48T

靈敏度：3.9 ng/mL

檢測范圍：15.6 ng/mL-1000 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ADAMTS5 Antibody

ADAMTS5 Protein

ADAMTS5 ELISA Kit

ADAMTS5 Antibodies

ADAMTS5 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA925454	ADAMTS5 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA198249	ADAMTS5 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA890943LA01HU	ADAMTS5 Antibody	Human	ELISA, IHC

ADAMTS5 Proteins

ADAMTS5 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP890943HU CSB-EP890943HU CSB-BP890943HU CSB-MP890943HU CSB-EP890943HU-B	Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli