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ADRB2

ADRB2,即β2腎上腺素能受體,別名β2-AR。ADRB2是一種G蛋白偶聯(lián)受體(GPCR),主要在氣道平滑肌細(xì)胞、血管平滑肌、心肌等組織細(xì)胞中表達(dá)。ADRB2的作用機(jī)制主要是通過其受體激活,導(dǎo)致細(xì)胞內(nèi)cAMP水平增加,進(jìn)一步激活PKA,促進(jìn)底物磷酸化,從而引起平滑肌松弛,解除支氣管痙攣等癥狀。ADRB2激動(dòng)劑是治療哮喘和慢性阻塞性肺?。–OPD)等呼吸系統(tǒng)疾病的重要藥物,根據(jù)其作用持續(xù)時(shí)間,它們被分為短效(SABA)、長(zhǎng)效(LABA)和超長(zhǎng)效(Ultra-LABA)β-激動(dòng)劑。ADRB2是氣道平滑肌張力的重要調(diào)節(jié)劑,其功能異常與多種疾病的發(fā)生發(fā)展有關(guān),包括夜間哮喘、肥胖、2型糖尿病和心血管疾病。

熱銷產(chǎn)品

Recombinant Human Beta-2 adrenergic receptor(ADRB2)(G16R,E27Q)-VLPs (CSB-MP001392HU(M))

驗(yàn)證數(shù)據(jù)

CSB-MP001392HU(M)

CSB-MP001392HU(M) is detected by Mouse anti-6*His monoclonal antibody.

CSB-MP001392HU(M)

The purity of VLPs was greater than 95% as determined by SEC-HPLC

ADRB2 Recombinant Monoclonal Antibody (CSB-RA286054A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA286054A0HU

IHC image of CSB-RA286054A0HU diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA286054A0HU

IHC image of CSB-RA286054A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

ADRB2 Antibodies

ADRB2 for Homo sapiens (Human)

ADRB2 for Rattus norvegicus (Rat)

ADRB2 Proteins

ADRB2 Proteins for Rattus norvegicus (Rat)

ADRB2 Proteins for Mus musculus (Mouse)

ADRB2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ADRB2 Proteins for Mesocricetus auratus (Golden hamster)

ADRB2 Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

ADRB2 Proteins for Sus scrofa (Pig)

ADRB2 Proteins for Macaca mulatta (Rhesus macaque)

ADRB2 Proteins for Bos taurus (Bovine)

ADRB2 Proteins for Tscherskia triton (Greater long-tailed hamster)

ADRB2 Proteins for Cavia porcellus (Guinea pig)

ADRB2 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

ADRB2 Proteins for Felis catus (Cat) (Felis silvestris catus)

ADRB2 Proteins for Homo sapiens (Human)