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ALCAM

活化白細胞黏附分子(ALCAM)又稱CD166,是一種跨膜糖蛋白,屬于免疫球蛋白超家族成員。它在胚胎發(fā)育、神經(jīng)軸突導(dǎo)向及免疫細胞遷移中發(fā)揮關(guān)鍵作用,通過與受體相互作用介導(dǎo)同型或異型細胞黏附。ALCAM異常表達與多種腫瘤密切相關(guān),乳腺癌、結(jié)直腸癌中ALCAM高表達常伴隨侵襲轉(zhuǎn)移能力增強,而前列腺癌中其表達缺失反而促進腫瘤進展,這種"雙刃劍"特性使其成為癌癥研究熱點。在神經(jīng)領(lǐng)域,阿爾茨海默病患者腦脊液中可檢測到ALCAM水平升高,提示其參與神經(jīng)炎癥過程。近年來針對ALCAR的靶向藥物研發(fā)集中在單克隆抗體方向,實驗顯示阻斷ALCAM能抑制黑色素瘤細胞肺轉(zhuǎn)移。其復(fù)雜的功能網(wǎng)絡(luò)還涉及干細胞niche維持,在骨髓微環(huán)境中調(diào)控造血干細胞的定位與增殖。

熱銷產(chǎn)品

Recombinant Human CD166 antigen (ALCAM), partial (CSB-EP614444HU)

驗證數(shù)據(jù)

CSB-EP614444HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ALCAM Recombinant Monoclonal Antibody (CSB-RA437652A0HU)

驗證數(shù)據(jù)

CSB-RA437652A0HU

Western Blot
Positive WB detected in: PC3 whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, U251 whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate, Ntera-2 whole cell lysate, Mouse brain tissue
All lanes: ALCAM antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 66, 64, 16, 34 kDa
Observed band size: 100 kDa

CSB-RA437652A0HU

IHC image of CSB-RA437652A0HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA437652A0HU

IHC image of CSB-RA437652A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

ALCAM Antibodies

ALCAM for Homo sapiens (Human)

ALCAM Proteins

ALCAM Proteins for Gallus gallus (Chicken)

ALCAM Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ALCAM Proteins for Oryctolagus cuniculus (Rabbit)

ALCAM Proteins for Rattus norvegicus (Rat)

ALCAM Proteins for Homo sapiens (Human)

ALCAM Proteins for Mus musculus (Mouse)

ALCAM Proteins for Carassius auratus (Goldfish)

ALCAM Proteins for Bos taurus (Bovine)

ALCAM ELISA Kit

ALCAM ELISA Kit for Homo sapiens (Human)