AMHR2

抗繆勒氏管激素II型受體（AMHR2）又稱繆勒抑制物質受體II型，在性別分化過程中具有關鍵調控作用。該受體主要分布于性腺組織，通過與抗繆勒氏管激素（AMH）特異性結合，激活SMAD信號級聯(lián)反應，進而抑制女性生殖管道的發(fā)育。臨床研究發(fā)現(xiàn)，AMHR2基因突變可導致持續(xù)性繆勒管綜合征，出現(xiàn)子宮、輸卵管殘留等生殖系統(tǒng)異常。近年來該受體在婦科腫瘤領域備受關注，約80%的卵巢顆粒細胞瘤存在AMHR2過表達現(xiàn)象，其激活狀態(tài)與腫瘤增殖、轉移密切相關。針對AMHR2的治療策略已進入轉化階段，單克隆抗體藥物STRO-002已完成治療卵巢癌的I期臨床試驗，小分子抑制劑KY-273也在臨床前研究中顯示出抑制腫瘤生長的潛力。

熱銷產品

AMHR2 Antibody (CSB-PA614985ESR1HU)

驗證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human adrenal glands tissue using CSB-PA614985ESR1HU at dilution of 1:50

Immunofluorescence staining of HepG2 cells with CSB-PA614985ESR1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Anti-Muellerian hormone type-2 receptor(AMHR2) ELISA kit (CSB-EL001667HU)

驗證數(shù)據(jù)

貨號：CSB-EL001667HU

規(guī)格：96T/48T

靈敏度：8 pg/mL

檢測范圍：0.32 ng/mL-12 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

AMHR2 Antibody

AMHR2 Protein

AMHR2 ELISA Kit

AMHR2 Antibodies

AMHR2 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA614985ESR1HU	AMHR2 Antibody	Human	ELISA, IHC, IF
CSB-PA311389	AMHR2 Antibody	Human,Mouse,Rat	ELISA,IHC

AMHR2 Proteins

AMHR2 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP614985HU CSB-EP614985HU CSB-BP614985HU CSB-MP614985HU CSB-EP614985HU-B	Recombinant Human Anti-Muellerian hormone type-2 receptor (AMHR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli