ANGPTL3

ANGPTL，即血管生成素樣蛋白3，別名AGPTL3。ANGPTL3主要在肝臟中表達，由ANGPTL3基因編碼，并且其表達受肝X受體（LXR）的調(diào)控。ANGPTL3通過抑制脂蛋白脂酶（LPL）和內(nèi)皮脂酶（EL）的活性，從而減少乳糜微粒和極低密度脂蛋白（VLDL）中的甘油三酯被水解，這導致LDL-C、VLDL-C、HDL-C以及甘油三酯（TG）水平的降低。ANGPTL3的這種抑制作用對調(diào)節(jié)血脂水平和降低心血管風險具有重要意義。ANGPTL3的功能不僅在脂質(zhì)代謝中發(fā)揮關(guān)鍵作用，還與動脈粥樣硬化性心血管疾病的風險降低有關(guān)。研究表明，ANGPTL3功能缺失突變的攜帶者具有更低的三酰甘油、HDL-C和LDL-C水平，并且冠心病的發(fā)病率也顯著下降。因此，ANGPTL3成為了降脂治療的新興靶點，針對ANGPTL3的藥物研發(fā)，如單克隆抗體Evinacumab和反義寡核苷酸Vupanorsen，已經(jīng)在臨床試驗中顯示出降低血脂水平的潛力。

熱銷產(chǎn)品

ANGPTL3 Antibody (CSB-PA169214)

驗證數(shù)據(jù)

Gel: 10%SDS-PAGE Lysate: 30 ug Human liver cancer tissue lysate Primary antibody: 1/400 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/ 3000 dilution Exposure time: 1 minute

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 31029(ANGPTL3 Antibody) at dilution 1/8, on the right is treated with the fusion protein.

ANGPTL3 Antibody

ANGPTL3 Protein

ANGPTL3 ELISA Kit

ANGPTL3 Antibodies

ANGPTL3 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA001711GA01HU	ANGPTL3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA169214	ANGPTL3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA05759A0Rb	ANGPTL3 Antibody	Human	ELISA, IHC
CSB-PA05759D0Rb	ANGPTL3 Antibody, Biotin conjugated	Human	ELISA

ANGPTL3 Proteins

ANGPTL3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP874172MO CSB-BP874172MO CSB-MP874172MO CSB-EP874172MO-B	Recombinant Mouse Angiopoietin-related protein 3 (Angptl3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ANGPTL3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP896903HU CSB-EP896903HU CSB-BP896903HU CSB-MP896903HU CSB-EP896903HU-B	Recombinant Human Angiopoietin-related protein 3 (ANGPTL3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli