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ANPEP

ANPEP全稱為丙氨酰氨肽酶,又稱CD13或膜氨肽酶N,是一種廣泛分布于上皮細(xì)胞、免疫細(xì)胞及血管內(nèi)皮細(xì)胞表面的跨膜蛋白。ANPEP通過水解多肽鏈N末端的丙氨酸殘基參與調(diào)控細(xì)胞信號(hào)傳導(dǎo),在腫瘤微環(huán)境中可促進(jìn)新生血管形成并介導(dǎo)免疫逃逸,其異常表達(dá)與多種惡性腫瘤密切相關(guān),如急性髓系白血病、肝癌及胃癌的轉(zhuǎn)移進(jìn)程均觀察到CD13活性升高。ANPEP在類風(fēng)濕性關(guān)節(jié)炎、炎癥性腸病等免疫性疾病中也被發(fā)現(xiàn)參與炎癥細(xì)胞浸潤(rùn)過程。針對(duì)CD13的靶向藥物開發(fā)已有突破,烏苯美司作為氨肽酶抑制劑已用于臨床輔助抗癌治療,而新型小分子抑制劑Tosedostat在復(fù)發(fā)型血液腫瘤的II期試驗(yàn)中展現(xiàn)出潛力。近年來CAR-T療法中CD13也被探索為實(shí)體瘤治療靶點(diǎn),但其在正常組織的廣泛表達(dá)仍是藥物研發(fā)需要攻克的主要障礙。

熱銷產(chǎn)品

Recombinant Human Aminopeptidase N (ANPEP), partial (CSB-EP001827HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP001827HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ANPEP Recombinant Monoclonal Antibody (CSB-RA001827MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA001827MA1HU

Immunofluorescence staining of HEPG2 cell with CSB-RA001827MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA001827MA1HU

Immunofluorescence staining of A549 cell with CSB-RA001827MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).

CSB-RA001827MA1HU

Overlay Peak curve showing 293 cells surface stained with CSB-RA001827MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,026 events was performed.

Human alanyl (membrane) aminopeptidase (ANPEP)ELISA kit (CSB-EL001827HU)

驗(yàn)證數(shù)據(jù)

CSB-EL001827HU 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-EL001827HU

規(guī)格:96T/48T

靈敏度:7.81 pg/mL

檢測(cè)范圍:31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ANPEP Antibodies

ANPEP for Homo sapiens (Human)

ANPEP Proteins

ANPEP Proteins for Felis catus (Cat) (Felis silvestris catus)

ANPEP Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

ANPEP Proteins for Bos taurus (Bovine)

ANPEP Proteins for Mus musculus (Mouse)

ANPEP Proteins for Sus scrofa (Pig)

ANPEP Proteins for Homo sapiens (Human)

ANPEP Proteins for Oryctolagus cuniculus (Rabbit)

ANPEP Proteins for Gallus gallus (Chicken)

ANPEP Proteins for Rattus norvegicus (Rat)

ANPEP ELISA Kit

ANPEP ELISA Kit for Homo sapiens (Human)

ANPEP ELISA Kit for Mus musculus (Mouse)