APCS（腺苷三磷酸環(huán)化酶誘導(dǎo)的磷酸二酯酶）是一種關(guān)鍵的酶，在細(xì)胞內(nèi)信號(hào)轉(zhuǎn)導(dǎo)中發(fā)揮著重要作用。它能夠?qū)TP轉(zhuǎn)化為環(huán)磷酸腺苷（cAMP），從而調(diào)節(jié)多種生理過(guò)程。APCS的蛋白全名為腺苷三磷酸環(huán)化酶誘導(dǎo)的磷酸二酯酶1，常見(jiàn)別名為cAMP磷酸二酯酶。APCS主要存在于細(xì)胞質(zhì)中，并在多種組織中表達(dá)。它的活性受到多種因素的調(diào)節(jié)，包括細(xì)胞內(nèi)cAMP水平、Ca2+濃度和激素信號(hào)。APCS參與多種信號(hào)通路，如蛋白激酶A（PKA）通路、蛋白激酶C（PKC）通路和MAPK通路。這些通路與細(xì)胞生長(zhǎng)、分化和凋亡密切相關(guān)。APCS與多種疾病的發(fā)生發(fā)展有關(guān)，如癌癥、糖尿病和心血管疾病。在藥物研發(fā)方面，針對(duì)APCS的抑制劑和激活劑已被用于治療多種疾病，如癌癥、糖尿病和哮喘。例如，西羅莫司是一種APCS抑制劑，可用于治療某些類(lèi)型的癌癥。此外，一些藥物可以增強(qiáng)APCS的活性，從而提高細(xì)胞內(nèi)cAMP水平，用于治療某些類(lèi)型的疾病。

熱銷(xiāo)產(chǎn)品

Recombinant Human Serum amyloid P-component (APCS) (CSB-EP001898HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

APCS Recombinant Monoclonal Antibody (CSB-RA001898MA1HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA001898MA1HUU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.