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APP

APP(Amyloid Precursor Protein)的主要功能是參與神經(jīng)細(xì)胞的生長(zhǎng)、發(fā)育和修復(fù),并影響突觸形成和可塑性。他的結(jié)構(gòu)包括一個(gè)N端信號(hào)肽、大約660個(gè)氨基酸組成的外顯區(qū)域,以及一個(gè)C端跨膜區(qū)和胞內(nèi)區(qū)域。在正常情況下,APP會(huì)通過(guò)非淀粉樣途徑被酶解,產(chǎn)生具有生理功能的代謝產(chǎn)物。然而,異常的代謝途徑可能導(dǎo)致β-淀粉樣蛋白(β-amyloid)的積聚,這是阿爾茨海默病的主要病理特征之一。APP信號(hào)通路涉及多種酶的參與,包括α、β和γ-分泌酶。這些酶的活性和調(diào)控對(duì)APP代謝產(chǎn)物的生成和去除至關(guān)重要。在研究和臨床應(yīng)用方面,APP和其代謝產(chǎn)物被廣泛用于阿爾茨海默病的診斷和治療研究。

熱銷產(chǎn)品

APP Recombinant Monoclonal Antibody (Code:CSB-RA994273A0HU)

驗(yàn)證數(shù)據(jù)

WB
CSB-RA994273A0HU WB

Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HEK293 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Amyloid beta A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 35, 77, 79, 79, 81, 83, 85, 86, 73, 85 kDa
Observed band size: 100 kDa

IF
CSB-RA994273A0HU IF

Immunofluorescence staining of Hela Cells with CSB-RA994273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).


APP Antibodies

APP for Homo sapiens (Human)

APP Proteins

APP Proteins for Homo sapiens (Human)