APP
APP(Amyloid Precursor Protein)的主要功能是參與神經(jīng)細(xì)胞的生長(zhǎng)、發(fā)育和修復(fù),并影響突觸形成和可塑性。他的結(jié)構(gòu)包括一個(gè)N端信號(hào)肽、大約660個(gè)氨基酸組成的外顯區(qū)域,以及一個(gè)C端跨膜區(qū)和胞內(nèi)區(qū)域。在正常情況下,APP會(huì)通過(guò)非淀粉樣途徑被酶解,產(chǎn)生具有生理功能的代謝產(chǎn)物。然而,異常的代謝途徑可能導(dǎo)致β-淀粉樣蛋白(β-amyloid)的積聚,這是阿爾茨海默病的主要病理特征之一。APP信號(hào)通路涉及多種酶的參與,包括α、β和γ-分泌酶。這些酶的活性和調(diào)控對(duì)APP代謝產(chǎn)物的生成和去除至關(guān)重要。在研究和臨床應(yīng)用方面,APP和其代謝產(chǎn)物被廣泛用于阿爾茨海默病的診斷和治療研究。
熱銷產(chǎn)品
APP Recombinant Monoclonal Antibody (Code:CSB-RA994273A0HU)
驗(yàn)證數(shù)據(jù)

Positive WB detected in: Hela whole cell lysate, A375 whole cell lysate, HEK293 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: Amyloid beta A4 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 35, 77, 79, 79, 81, 83, 85, 86, 73, 85 kDa
Observed band size: 100 kDa

Immunofluorescence staining of Hela Cells with CSB-RA994273A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
APP Antibodies
APP for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA07174A0Rb | APP Antibody | Human | ELISA, IHC |
CSB-PA07174B0Rb | APP Antibody, HRP conjugated | Human | ELISA |
CSB-PA07174C0Rb | APP Antibody, FITC conjugated | Human | |
CSB-PA07174D0Rb | APP Antibody, Biotin conjugated | Human | ELISA |
CSB-PA001950GA01HU | APP Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA001950OJ01HU | APP Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA001950NJ01HU | APP Antibody | Human | ELISA, WB |
CSB-PA07179A0Rb | APP Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA07179B0Rb | APP Antibody, HRP conjugated | Human | ELISA |
CSB-PA07179C0Rb | APP Antibody, FITC conjugated | Human | |
CSB-PA07179D0Rb | APP Antibody, Biotin conjugated | Human | ELISA |
CSB-MA0019501A0m | APP Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CSB-PA296382 | Phospho-APP (Thr668) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA907645 | APP (Ab-668) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
CSB-PA212801 | Phospho-APP (Thr743/668) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA000724 | Phospho-APP (T743) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA000875 | APP Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA123968 | APP Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-RA994273A0HU | APP Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB, IF |
CSB-RA001950MA2HU | APP (GSK933776) Recombinant Monoclonal Antibody | Human | ELISA, IHC, IF |
CSB-RA001950MA3HU | APP (sabirnetug) Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
APP Proteins
APP Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-CF001950HU | Recombinant Human Amyloid-beta precursor protein(APP) | in vitro E.coli expression system |