APRIL
APRIL，即增殖誘導(dǎo)配體，別名CD256、TNFSF13。它是一種主要由髓系細(xì)胞產(chǎn)生的蛋白質(zhì)，包括常規(guī)樹突狀細(xì)胞、濾泡DC、單核細(xì)胞、中性粒細(xì)胞和巨噬細(xì)胞，活化的B細(xì)胞也少量產(chǎn)生APRIL。APRIL的作用機(jī)制涉及與其受體TACI、BCMA和HSPG的結(jié)合，通過這些相互作用參與調(diào)節(jié)B細(xì)胞的激活、漿細(xì)胞的存活以及免疫球蛋白的同種型轉(zhuǎn)換。APRIL在多種生理過程中發(fā)揮作用，包括B細(xì)胞的成熟、抗體的類別轉(zhuǎn)換以及長壽命漿細(xì)胞的形成。此外，APRIL在多種疾病中也有重要作用，包括自身免疫性疾病如系統(tǒng)性紅斑狼瘡(SLE)和IgA腎病(IgAN)，以及多種類型的癌癥，如乳腺癌、結(jié)直腸癌和非小細(xì)胞肺癌等。APRIL的異常表達(dá)與腫瘤細(xì)胞的增殖、存活和侵襲有關(guān)，使其成為潛在的治療靶點(diǎn)。
熱銷產(chǎn)品
TNFSF13 Antibody (CSB-PA023989ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Tumor necrosis factor ligand superfamily member 13 antibody at 10μg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 28, 26, 25, 37, 23 kDa
Observed band size: 28 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA023989ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023989ESR1HU at dilution of 1:100
Human a proliferation inducing ligand(APRIL)ELISA Kit (CSB-E15012h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E15012h
規(guī)格：96T/48T
靈敏度：0.195 ng/mL
檢測范圍：0.78 ng/mL-50 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
APRIL Antibodies
APRIL for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023989GA01HU | TNFSF13 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA023989ESR1HU | TNFSF13 Antibody | Human | ELISA, WB, IHC |
| CSB-PA023989ESR2HU | TNFSF13 Antibody | Human | ELISA, IHC |
| CSB-PA244663 | TNFSF13 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA000909 | TNFSF13 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA877550 | TNFSF13 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA935662 | TNFSF13 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA599200 | TNFSF13 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA587516 | TNFSF13 Antibody | Human,Mouse | ELISA,IHC |
APRIL Proteins
APRIL Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023989HU CSB-EP023989HU CSB-BP023989HU CSB-EP023989HU-B |
Recombinant Human Tumor necrosis factor ligand superfamily member 13 (TNFSF13) | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
APRIL ELISA Kit
APRIL ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E15012h | Human a proliferation inducing ligand(APRIL)ELISA Kit | serum, plasma, urine | 0.195 ng/mL |
