AQP4，即水通道蛋白4，別名MGC22454、MIWC、WCH4。AQP4主要在中樞神經(jīng)系統(tǒng)的星形膠質(zhì)細(xì)胞中表達(dá)，尤其在細(xì)胞終足部分，對維持腦內(nèi)水和鉀離子平衡發(fā)揮關(guān)鍵作用。AQP4的作用機(jī)制涉及形成水分子的通道，允許水分子根據(jù)滲透梯度快速通過細(xì)胞膜，從而參與調(diào)節(jié)腦脊液的產(chǎn)生、內(nèi)環(huán)境穩(wěn)定以及神經(jīng)系統(tǒng)的水和鉀離子平衡。AQP4參與了多種神經(jīng)系統(tǒng)疾病的發(fā)生發(fā)展，如腦水腫、缺血性腦卒中、神經(jīng)炎癥等，其表達(dá)水平的變化與疾病的嚴(yán)重程度和預(yù)后密切相關(guān)。AQP4還與視神經(jīng)脊髓炎譜系疾?。∟MOSD）緊密相關(guān)，AQP4抗體陽性患者的病變分布與AQP4的分布高度相關(guān)，特征性病灶位于視神經(jīng)、脊髓、間腦和后腦區(qū)。AQP4在中樞神經(jīng)系統(tǒng)疾病的診斷和治療中具有重要的生物學(xué)意義。

熱銷產(chǎn)品

Recombinant Human Aquaporin-4 (AQP4), partial (CSB-EP001964HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

AQP4 Recombinant Monoclonal Antibody (CSB-RA548145A0HU)

驗證數(shù)據(jù)

IHC image of CSB-RA548145A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.33% DAB.