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ARF1

ARF1,即ADP-核糖基化因子1,別名PVNH8。ARF1由人類ARF1基因編碼,該基因位于1號(hào)染色體的1q42.13區(qū)域。ARF1是一種小GTP結(jié)合蛋白,屬于Ras超家族成員,其主要功能是刺激霍亂毒素的ADP-核糖基轉(zhuǎn)移酶活性,并作為磷脂酶D的激活劑在囊泡運(yùn)輸中發(fā)揮作用。ARF1蛋白定位于高爾基體,在高爾基體內(nèi)部運(yùn)輸中起著核心作用,通過激活膜上的磷脂酰肌醇4-磷酸酸酯酶和磷脂酰肌醇轉(zhuǎn)移酶,調(diào)節(jié)膜脂組成。ARF1在細(xì)胞內(nèi)膜系統(tǒng)的功能調(diào)節(jié)中扮演著關(guān)鍵角色,參與調(diào)控囊泡的形成、運(yùn)輸及膜交換過程。ARF1功能異常與多種細(xì)胞運(yùn)輸障礙疾病有關(guān),且在某些癌癥中的表達(dá)異常,可能與腫瘤的生長(zhǎng)和轉(zhuǎn)移相關(guān)。

熱銷產(chǎn)品

Recombinant Human ADP-ribosylation factor 1 (ARF1) (CSB-EP001988HUa2)

驗(yàn)證數(shù)據(jù)

CSB-EP001988HUa2

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ARF1 Antibody (CSB-PA00929A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA00929A0Rb

Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA00929A0Rb at dilution of 1:100

CSB-PA00929A0Rb

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA00929A0Rb at dilution of 1:100

CSB-PA00929A0Rb

Immunofluorescent analysis of Hela cells using CSB-PA00929A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

ARF1 Antibodies

ARF1 for Homo sapiens (Human)

ARF1 Proteins

ARF1 Proteins for Homo sapiens (Human)

ARF1 Proteins for Rattus norvegicus (Rat)

ARF1 Proteins for Mus musculus (Mouse)

ARF1 Proteins for Bos taurus (Bovine)

ARF1 Proteins for Catharanthus roseus (Madagascar periwinkle) (Vinca rosea)

ARF1 Proteins for Salix bakko (Japanese willow)

ARF1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ARF1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

ARF1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ARF1 Proteins for Xenopus laevis (African clawed frog)

ARF1 Proteins for Daucus carota (Carrot)

ARF1 Proteins for Chlamydomonas reinhardtii (Chlamydomonas smithii)

ARF1 Proteins for Locusta migratoria (Migratory locust)

ARF1 Proteins for Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

ARF1 Proteins for Zea mays (Maize)

ARF1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

ARF1 Proteins for Plasmodium falciparum (isolate 3D7)

ARF1 Proteins for Plasmodium falciparum

ARF1 Proteins for Brassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis)

ARF1 Proteins for Plasmodium falciparum (isolate NF54)

ARF1 Proteins for Oryza sativa subsp. japonica (Rice)

ARF1 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)