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ARG2

ARG2,全稱為Arginase type II,是一種在肝外組織中表達(dá)的酶,尤其在腎臟中高度表達(dá)。它也被稱為Arginase-2或ARG2,是一種參與尿素循環(huán)的酶,能夠催化精氨酸水解為鳥(niǎo)氨酸和尿素。ARG2蛋白在細(xì)胞內(nèi)的定位主要是在線粒體中,其功能與一氧化氮和多胺代謝密切相關(guān)。
ARG2蛋白在疾病發(fā)生發(fā)展中扮演著重要角色。研究表明,ARG2蛋白的表達(dá)異常與多種疾病相關(guān),包括癌癥、神經(jīng)退行性疾病和免疫疾病等。例如,在癌癥中,ARG2蛋白的表達(dá)水平與腫瘤的生長(zhǎng)和轉(zhuǎn)移密切相關(guān);在神經(jīng)退行性疾病中,ARG2蛋白的異常表達(dá)可能導(dǎo)致神經(jīng)元死亡和神經(jīng)功能退化;在免疫疾病中,ARG2蛋白的表達(dá)異??赡苡绊懨庖呒?xì)胞的活性和功能。
針對(duì)ARG2蛋白的藥物研發(fā)也在不斷進(jìn)行中。目前,研究人員正在開(kāi)發(fā)多種針對(duì)ARG2蛋白的抑制劑,以期通過(guò)抑制ARG2蛋白的表達(dá)或活性來(lái)治療相關(guān)疾病。例如,有研究表明,ARG2蛋白抑制劑可以抑制腫瘤的生長(zhǎng)和轉(zhuǎn)移,并提高免疫治療的療效。

熱銷產(chǎn)品

Recombinant Human Arginase-2, mitochondrial (ARG2) (CSB-EP002006HU)

驗(yàn)證數(shù)據(jù)

CSB-EP002006HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ARG2 Recombinant Monoclonal Antibody (CSB-RA216908A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA216908A0HU

IHC image of CSB-RA216908A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA216908A0HU

Immunofluorescence staining of PC-3 cell with CSB-RA216908A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 559-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA216908A0HU

Overlay Peak curve showing PC3 cells stained with CSB-RA216908A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human Arginase 2(ARG2) ELISA Kit (CSB-E14913h)

驗(yàn)證數(shù)據(jù)

CSB-E14913h 標(biāo)準(zhǔn)曲線

貨號(hào):CSB-E14913h

規(guī)格:96T/48T

靈敏度:0.12 mU/mL

檢測(cè)范圍:0.47 mU/mL-30 mU/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ARG2 Antibodies

ARG2 for Homo sapiens (Human)

ARG2 Proteins

ARG2 Proteins for Homo sapiens (Human)

ARG2 ELISA Kit

ARG2 ELISA Kit for Homo sapiens (Human)