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BAFF

BAFF(B細胞激活因子)是一種由髓系細胞產生的細胞因子,屬于腫瘤壞死因子家族,對B細胞的存活、增殖、抗原呈遞以及類別轉換重組起著至關重要的作用。它通過與三種受體(TNFRSF13B/TACI、TNFRSF17/BCMA、TNFRSF13C/BAFFR)結合,激活多種信號通路,包括NF-κB、MAPK(絲裂原活化蛋白激酶)和PI3K/AKT等,這些信號通路在B細胞的生物學過程以及免疫調節(jié)中發(fā)揮著重要作用。然而,BAFF的過度產生和激活也可能導致自身免疫性疾病的發(fā)生。因此,對BAFF的結構功能及其參與的信號通路的深入研究,對于理解其在免疫系統(tǒng)中的作用機制以及開發(fā)相關疾病的治療方法具有重要意義。

熱銷產品

Recombinant Human Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), partial (Active) (CSB-MP897523HU1)

驗證數據

CSB-MP897523HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP897523HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC50 of human TNFSF13B protein is 221.3-298.6 ng/ml.

CSB-MP897523HU1

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP897523HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 2 μg/ml can bind TNFRSF13C(CSB-MP853495HU1), the EC50 is 9.943-15.72 ng/ml.

CSB-MP897523HU1

The purity of TNFSF13B was greater than 90% as determined by SEC-HPLC

BAFF Antibodies

BAFF for Homo sapiens (Human)

BAFF ELISA Kit

BAFF ELISA Kit for Homo sapiens (Human)