BCAM
BCAM蛋白全稱為基底細(xì)胞黏附分子，也被稱為Lutheran血型抗原或CD239，是一種跨膜糖蛋白。該蛋白主要表達(dá)于紅細(xì)胞、上皮細(xì)胞及多種腫瘤細(xì)胞表面，通過與細(xì)胞外基質(zhì)中的層粘連蛋白結(jié)合參與細(xì)胞黏附及遷移過程。研究發(fā)現(xiàn)BCAM在鐮狀細(xì)胞病中異常活躍，其與血管內(nèi)皮細(xì)胞的相互作用加劇了紅細(xì)胞的滯留，導(dǎo)致血管阻塞危象的發(fā)生。在惡性腫瘤領(lǐng)域，BCAM的高表達(dá)與卵巢癌、胰腺癌的轉(zhuǎn)移密切相關(guān)，可能通過激活特定激酶促進(jìn)腫瘤細(xì)胞侵襲。近年來針對BCAM的靶向治療逐漸受到關(guān)注，已有研究團(tuán)隊(duì)開發(fā)出阻斷BCAM與層粘連蛋白結(jié)合的單克隆抗體，在動(dòng)物模型中顯示出抑制腫瘤轉(zhuǎn)移的效果。2022年一項(xiàng)針對鐮狀細(xì)胞病的II期臨床試驗(yàn)中，BCAM抑制劑聯(lián)合抗凝血療法使患者疼痛危象發(fā)生率降低40%，目前該靶點(diǎn)的雙功能抗體藥物已進(jìn)入臨床前評估階段。
熱銷產(chǎn)品
BCAM Antibody (CSB-PA341920LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA341920LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA341920LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA341920LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
BCAM Antibodies
BCAM for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005864 | BCAM Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA908140 | BCAM Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA930807 | BCAM Antibody | Human | ELISA,WB |
| CSB-PA341920LA01HU | BCAM Antibody | Human | ELISA, IHC, IF |
BCAM Proteins
BCAM Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP341920HU CSB-EP341920HU CSB-BP341920HU CSB-MP341920HU CSB-EP341920HU-B |
Recombinant Human Basal cell adhesion molecule (BCAM), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
