BCAT2
支鏈氨基酸轉(zhuǎn)氨酶2(BCAT2)是一種線粒體酶,主要負(fù)責(zé)亮氨酸、異亮氨酸和纈氨酸三種支鏈氨基酸的代謝,通過催化其轉(zhuǎn)氨基反應(yīng)生成相應(yīng)的支鏈α-酮酸。該酶在肝臟、骨骼肌等能量代謝活躍的組織中高表達(dá),因其線粒體定位特征,也被稱為BCATm。研究發(fā)現(xiàn),BCAT2通過調(diào)控支鏈氨基酸分解代謝,影響細(xì)胞能量供應(yīng)和蛋白質(zhì)合成,其異常表達(dá)與代謝綜合征、糖尿病等疾病密切相關(guān)。近年來在腫瘤領(lǐng)域,BCAT2被發(fā)現(xiàn)可通過維持白血病干細(xì)胞內(nèi)支鏈氨基酸水平,促進(jìn)急性髓系白血病進(jìn)展,成為潛在治療靶點(diǎn)。目前針對(duì)BCAT2的藥物開發(fā)尚處于早期階段,有研究嘗試通過小分子抑制劑阻斷其酶活性,但尚無進(jìn)入臨床試驗(yàn)的候選藥物。值得注意的是,由于支鏈氨基酸代謝與mTOR信號(hào)通路的交互作用,針對(duì)該酶的調(diào)控可能為代謝性疾病和癌癥治療提供新思路。
熱銷產(chǎn)品
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) (CSB-EP002601HU)
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCAT2 Antibody (CSB-PA002601LA01HU)
驗(yàn)證數(shù)據(jù)

Western blot
All lanes: BCAT2 antibody at 2µg/ml
Lane 1: NIH/3T3 whole cell lysate
Lane 2: Mouse kidney tissue
Lane 3: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 45, 34 kDa
Observed band size: 45 kDa

Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA002601LA01HU at dilution of 1:100
BCAT2 Antibodies
BCAT2 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA002601GA01HU | BCAT2 Antibody | Human,Mouse | ELISA,WB |
CSB-PA002601LA01HU | BCAT2 Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-PA002601ESR1HU | BCAT2 Antibody | Human | ELISA, WB, IHC |
CSB-PA842510 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA129399 | BCAT2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
BCAT2 Proteins
BCAT2 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP002601HU CSB-BP002601HU CSB-MP002601HU CSB-EP002601HU-B |
Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP002601HU | Recombinant Human Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) | E.coli |