搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

Your Good Partner in Biology Research

BRD4

BRD4,即溴結(jié)構(gòu)域蛋白4,別名BRD4。BRD4是一種屬于溴結(jié)構(gòu)域和超末端結(jié)構(gòu)域(BET)家族的蛋白,主要通過識別乙?;M蛋白來調(diào)節(jié)基因表達。BRD4的作用機制主要涉及其與轉(zhuǎn)錄因子的相互作用。BRD4通過其兩個溴結(jié)構(gòu)域(BD1和BD2)結(jié)合乙?;慕M蛋白,定位于目標(biāo)基因的啟動子或增強子區(qū)域,促進相關(guān)基因的轉(zhuǎn)錄。此外,BRD4還通過招募轉(zhuǎn)錄延伸因子和其他調(diào)節(jié)因子,增強RNA聚合酶II的活性,從而促進基因的轉(zhuǎn)錄伸長。BRD4在細胞周期、增殖和凋亡等生理過程中起著關(guān)鍵作用。研究表明,BRD4的異常表達與多種惡性腫瘤的發(fā)生發(fā)展相關(guān),包括急性髓系白血病、多發(fā)性骨髓瘤、乳腺癌和膠質(zhì)母細胞瘤等。BRD4不僅參與腫瘤細胞的增殖和轉(zhuǎn)移,還在DNA損傷修復(fù)和端粒維持中發(fā)揮重要作用。因此,BRD4成為了癌癥治療的一個重要靶點。

熱銷產(chǎn)品

Recombinant Human Bromodomain-containing protein 4 (BRD4), partial (CSB-EP002802HU)

驗證數(shù)據(jù)

CSB-EP002802HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BRD4 Recombinant Monoclonal Antibody (CSB-RA152430A0HU)

驗證數(shù)據(jù)

CSB-RA152430A0HU

Western Blot
Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, A549 whole cell lysate
All lanes: BRD4 antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 153, 81, 89 kDa
Observed band size: 153 kDa

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA152430A0HU

IHC image of CSB-RA152430A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

BRD4 Antibodies

BRD4 for Homo sapiens (Human)

BRD4 Proteins

BRD4 Proteins for Homo sapiens (Human)

BRD4 Proteins for Mus musculus (Mouse)

BRD4 ELISA Kit

BRD4 ELISA Kit for Homo sapiens (Human)