BTK，即布魯頓酪氨酸激酶，別名AGMX1 ATK BPK。它是一種非受體酪氨酸激酶，屬于Tec激酶家族成員，在所有造血細(xì)胞中廣泛存在，除了T細(xì)胞和漿細(xì)胞。BTK的作用機(jī)制主要是通過(guò)參與B細(xì)胞受體（BCR）信號(hào)通路，傳遞BCR接受到的信號(hào)并調(diào)控B細(xì)胞的增殖和存活。BTK包含5個(gè)結(jié)構(gòu)域：PH結(jié)構(gòu)域、TH結(jié)構(gòu)域、SH3結(jié)構(gòu)域、SH2結(jié)構(gòu)域和SH1/TK催化結(jié)構(gòu)域，這些結(jié)構(gòu)域可以識(shí)別并結(jié)合多種信號(hào)分子 。BTK在生物學(xué)上的意義非常廣泛，它不僅參與了B細(xì)胞的成熟、存活、分化、凋亡、遷移等過(guò)程，還涉及了多種疾病的發(fā)生發(fā)展，尤其是在B細(xì)胞淋巴瘤中，BTK是BCR信號(hào)通路中的關(guān)鍵激酶。BTK抑制劑可以與BTK活性中心的半胱氨酸殘基共價(jià)結(jié)合，從而抑制其活性，進(jìn)而抑制BCR信號(hào)通路的激活，有效阻止腫瘤從B細(xì)胞遷移至適宜腫瘤生長(zhǎng)的淋巴組織，減少B細(xì)胞惡性增殖并誘導(dǎo)細(xì)胞的凋亡，從而發(fā)揮治療作用 。

熱銷產(chǎn)品

Recombinant Human Tyrosine-protein kinase BTK (BTK) (CSB-BP002867HU(A4))

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

BTK Recombinant Monoclonal Antibody (CSB-RA553167A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA553167A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.