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BTLA

BTLA,即B和T淋巴細(xì)胞弱化因子,別名BTNL9、BTLA。它是一種主要在T細(xì)胞、B細(xì)胞和NK細(xì)胞上表達(dá)的免疫檢查點(diǎn)分子,由人體細(xì)胞自身的基因編碼。BTLA的作用機(jī)制涉及與其特異性配體HVEM(皰疹病毒入侵介質(zhì))結(jié)合,這種結(jié)合能夠抑制T細(xì)胞和B細(xì)胞的活化、增殖以及細(xì)胞因子的生成。BTLA與HVEM的結(jié)合通過激活免疫受體酪氨酸的抑制基序(ITIM)和免疫球蛋白酪氨酸開關(guān)基序(ITSM),導(dǎo)致SHP-1和SHP-2的磷酸化和募集,從而抑制T細(xì)胞的增殖和IL-2的產(chǎn)生,產(chǎn)生免疫抑制效應(yīng) 。BTLA參與了多種生理和病理過程的調(diào)節(jié),包括腫瘤、炎癥性疾病、自身免疫性疾病等。在腫瘤微環(huán)境中,BTLA的激活是PD-1抗體的潛在耐藥機(jī)制之一,BTLA的表達(dá)與腫瘤的進(jìn)展密切相關(guān)。在炎癥性疾病中,BTLA對(duì)T細(xì)胞介導(dǎo)的炎癥具有負(fù)調(diào)節(jié)作用。此外,在自身免疫性疾病中,BTLA的表達(dá)水平與疾病的活動(dòng)性相關(guān)。因此,BTLA是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn) 。

熱銷產(chǎn)品

Recombinant Human B- and T-lymphocyte attenuator (BTLA), partial (Active) (CSB-MP773799HU)

驗(yàn)證數(shù)據(jù)

CSB-MP773799HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP773799HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized BTLA at 5 μg/ml can bind biotinylated human TNFRSF14 (CSB-MP842173HU-A), the EC50 is 137.8-233.4 ng/ml.

CSB-MP773799HU

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human BTLA at 2μg/ml can bind Anti-BTLA recombinant antibody(CSB-RA773799MAIHU), the EC50 is 1.763-3.542 ng/mL.

BTLA Recombinant Monoclonal Antibody (CSB-RA773799MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA773799MA1HU

The Binding Activity of Human BTLA with Anti-BTLA Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human BTLA(CSB-MP773799HU1)at 2 μg/mL can bind Anti-BTLA recombinant antibody , the EC50 is 11.56-13.00 ng/mL.

CSB-RA773799MA1HU

Untransfected Jurkat cells surface (green line) and transfected Human BTLA Jurkat stable cells surface (red line) were stained with anti-BTLA antibody (2μg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-RA773799MA1HU

Untransfected CHO-K1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

BTLA Antibodies

BTLA for Homo sapiens (Human)

BTLA Proteins

BTLA Proteins for Mus musculus (Mouse)

BTLA Proteins for Rattus norvegicus (Rat)

BTLA Proteins for Homo sapiens (Human)

BTLA ELISA Kit

BTLA ELISA Kit for Homo sapiens (Human)

BTLA ELISA Kit for Mus musculus (Mouse)