C5，即補(bǔ)體成分5，別名C5α、C5b等。它是人類補(bǔ)體系統(tǒng)的一部分，由肝臟細(xì)胞產(chǎn)生，是一種血清蛋白。C5的作用機(jī)制主要是通過(guò)補(bǔ)體級(jí)聯(lián)反應(yīng)被激活，C5可以被C4b2a（經(jīng)典途徑和凝集素途徑）或C3bBb3b（旁路途徑）裂解為C5a和C5b兩個(gè)片段。C5a是一個(gè)具有強(qiáng)烈炎癥活性的小分子肽，能夠吸引和激活多種免疫細(xì)胞，如中性粒細(xì)胞和單核細(xì)胞，而C5b則啟動(dòng)膜攻擊復(fù)合物（MAC）的形成，導(dǎo)致外來(lái)細(xì)胞的溶解。C5在生物學(xué)上的意義非常廣泛，它在天然免疫和獲得性免疫之間起著橋梁作用。C5的活化參與了清除病原體和受損細(xì)胞、調(diào)節(jié)炎癥反應(yīng)、促進(jìn)免疫細(xì)胞的趨化和活化等重要過(guò)程。C5a-C5aR1信號(hào)通路在多種炎癥性疾病中發(fā)揮作用，包括結(jié)直腸癌等腫瘤的發(fā)展，通過(guò)影響免疫微環(huán)境和細(xì)胞內(nèi)信號(hào)傳導(dǎo)來(lái)促進(jìn)腫瘤的發(fā)生和發(fā)展。C5的異常活化與多種自身免疫性疾病和炎癥性疾病的發(fā)生發(fā)展密切相關(guān)，因此，C5或其受體C5aR1已成為藥物開(kāi)發(fā)的潛在靶點(diǎn) 。

熱銷產(chǎn)品

C5 Recombinant Monoclonal Antibody (CSB-RA003995MA1HU)

驗(yàn)證數(shù)據(jù)

Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10, 021 events was performed.