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CA1

CA1,即碳酸酐酶1,別名CAB/CAR1/CAN等。它是一種膜結(jié)合糖蛋白,屬于碳酸酐酶相關(guān)蛋白家族成員,主要在人體細(xì)胞的質(zhì)膜上表達(dá),尤其在肺、腎、前列腺和紅細(xì)胞中表達(dá)量較高。CA1的作用機(jī)制是通過催化二氧化碳(CO2)和水(H2O)之間的可逆反應(yīng),生成碳酸氫根離子(HCO3-)和質(zhì)子(H+),從而參與調(diào)節(jié)體內(nèi)酸堿平衡和氣體交換。這一過程對(duì)于維持血液pH值和促進(jìn)氧氣釋放至組織至關(guān)重要。CA1在生物學(xué)上的意義非常廣泛,它參與了多種生理過程,包括呼吸、代謝和酸堿平衡的維持。在肺中,CA1幫助調(diào)節(jié)氣體交換,促進(jìn)CO2的排出;在腎中,它參與碳酸氫鹽的重吸收,影響尿液的酸化;在前列腺中,CA1與腫瘤的酸化微環(huán)境有關(guān),可能影響腫瘤細(xì)胞的增殖和轉(zhuǎn)移。此外,CA1的活性還與某些遺傳性疾病相關(guān),例如,某些形式的II型碳酸酐酶缺乏癥與SLC45A1基因突變有關(guān)。因此,CA1不僅在維持生理功能中發(fā)揮關(guān)鍵作用,也是醫(yī)學(xué)研究和治療干預(yù)的潛在靶點(diǎn)。

熱銷產(chǎn)品

Recombinant Human Carbonic anhydrase 1 (CA1) (CSB-EP004364HU)

驗(yàn)證數(shù)據(jù)

CSB-EP004364HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CA1 Recombinant Monoclonal Antibody (CSB-RA217389A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA217389A0HU

Western Blot
Positive WB detected in: K562 whole cell lysate,U937 whole cell lysate
All lanes: Ikaros antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 28 kDa
Observed band size: 28 kDa

CSB-RA217389A0HU

IHC image of CSB-RA217389A0HU diluted at 1:50 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.36% DAB.

CSB-RA217389A0HU

Overlay Peak curve showing MCF-7 cells stained with CSB-RA217389A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CA1 Antibodies

CA1 for Homo sapiens (Human)

CA1 Proteins

CA1 Proteins for Homo sapiens (Human)

CA1 ELISA Kit

CA1 ELISA Kit for Homo sapiens (Human)