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CANX

鈣連接蛋白(Calnexin,別名IP90)是一種廣泛表達(dá)于內(nèi)質(zhì)網(wǎng)的分子伴侶蛋白,主要負(fù)責(zé)協(xié)助新生糖蛋白的正確折疊與質(zhì)量控制。CANX通過識別未完全折疊蛋白的糖基化修飾,與鈣網(wǎng)蛋白協(xié)同形成"折疊檢查系統(tǒng)",阻止錯(cuò)誤折疊蛋白分泌或促進(jìn)其進(jìn)入降解途徑。該蛋白在維持內(nèi)質(zhì)網(wǎng)穩(wěn)態(tài)中發(fā)揮關(guān)鍵作用,其功能異常與阿爾茨海默病、帕金森病等神經(jīng)退行性疾病密切相關(guān),錯(cuò)誤折疊蛋白的積累會(huì)觸發(fā)細(xì)胞凋亡通路。在腫瘤領(lǐng)域,某些癌細(xì)胞通過上調(diào)鈣連接蛋白增強(qiáng)應(yīng)激耐受性,促進(jìn)轉(zhuǎn)移和耐藥性形成。CANX還參與調(diào)控免疫細(xì)胞表面MHC-I類分子的組裝,影響抗原呈遞過程。針對其相關(guān)通路開發(fā)的分子伴侶抑制劑已進(jìn)入臨床前研究,如選擇性抑制內(nèi)質(zhì)網(wǎng)應(yīng)激通路的小分子化合物,在乳腺癌和骨髓瘤模型中顯示出增強(qiáng)化療敏感性的潛力?;谄涠嘀厣飳W(xué)功能,鈣連接蛋白已成為神經(jīng)疾病和腫瘤治療的新興靶點(diǎn)。

熱銷產(chǎn)品

CANX Monoclonal Antibody (CSB-MA004485A1m)

驗(yàn)證數(shù)據(jù)

CSB-MA004485A1m

Western Blot
Positive WB detected in: MCF7 whole cell lysate, U87 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, U251 whole cell lysate, K562 whole cell lysate
All lanes: CANX antibody at 1:2000
Secondary
Goat polyclonal to mouse IgG at 1/50000 dilution
Predicted band size: 68, 72, 56 kDa
Observed band size: 90 KDa
Exposure time:1min

CSB-MA004485A1m

Immunofluorescence staining of Hela cells with CANX CSB-MA004485A1m at 1:140, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L).

CSB-MA004485A1m

Immunofluorescence staining of HepG2 cells with CANX CSB-MA004485A1m at 1:140, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG (H+L).

CSB-MA004485A1m

Overlay Peak curve showing Hela cells stained with CSB-MA004485A1m (red line) at 1:140. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

CANX Antibodies

CANX for Homo sapiens (Human)

CANX Proteins

CANX Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

CANX Proteins for Mus musculus (Mouse)

CANX Proteins for Homo sapiens (Human)

CANX Proteins for Rattus norvegicus (Rat)

CANX Proteins for Pongo abelii (Sumatran orangutan)