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CAPRIN1

CAPRIN1,全稱為cell cycle associated protein 1,是一種細(xì)胞質(zhì)磷酸蛋白,在神經(jīng)元突觸可塑性和多種細(xì)胞類型的細(xì)胞增殖和遷移中發(fā)揮重要作用。該蛋白在腦部以外的組織中水平與細(xì)胞增殖密切相關(guān)。研究表明,抑制人類Caprin-1的表達(dá)會(huì)導(dǎo)致細(xì)胞增殖速率減慢,這表明其對(duì)于正常的細(xì)胞增殖至關(guān)重要。Caprin-1蛋白還與應(yīng)激顆粒的形成有關(guān),應(yīng)激顆粒是真核細(xì)胞質(zhì)中形成的細(xì)胞器,對(duì)各種應(yīng)激源做出反應(yīng),如熱激和滲透壓變化。Caprin-1和USP10是應(yīng)激顆粒的重要組成蛋白,它們通過(guò)結(jié)合G3BP1 NTF2L調(diào)節(jié)應(yīng)激顆粒的形成,但具有相反的功能:Caprin-1促進(jìn)應(yīng)激顆粒的形成,而USP10抑制應(yīng)激顆粒的形成。Caprin-1蛋白的相關(guān)疾病包括癌癥和一些神經(jīng)退行性疾病。目前,針對(duì)Caprin-1蛋白的藥物研發(fā)正在進(jìn)行中,例如東麗株式會(huì)社研發(fā)的人源化單克隆抗體TRK-950,正處于治療食道癌和胃癌的臨床二期研究階段。

熱銷產(chǎn)品

Recombinant Human Caprin-1 (CAPRIN1) (CSB-BP614529HU)

驗(yàn)證數(shù)據(jù)

CSB-BP614529HU

Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP614529HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) CAPRIN1.

CSB-BP614529HU

Based on the SEQUEST from database of Baculovirus host and target protein, the LC-MS/MS Analysis result of CSB-BP614529HU could indicate that this peptide derived from Baculovirus-expressed Homo sapiens (Human) CAPRIN1.

CAPRIN1 Antibody (CSB-PA614529LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA614529LA01HU

IHC image of CSB-PA614529LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA614529LA01HU

IHC image of CSB-PA614529LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA614529LA01HU

Immunofluorescence staining of Hela cells with CSB-PA614529LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CAPRIN1 Antibodies

CAPRIN1 for Homo sapiens (Human)

CAPRIN1 Proteins

CAPRIN1 Proteins for Homo sapiens (Human)