CCDC6
CCDC6是一種具有卷曲螺旋結(jié)構(gòu)域的蛋白質(zhì),其具體的三維結(jié)構(gòu)尚未完全解析,但已知它包含多個(gè)保守的氨基酸序列和特定的功能區(qū)域。在功能上,CCDC6參與細(xì)胞生長(zhǎng)、增殖和凋亡的調(diào)控,通過(guò)與其他蛋白質(zhì)相互作用形成復(fù)合物來(lái)發(fā)揮生物學(xué)作用。其生物學(xué)作用尤為重要,與多種疾病的發(fā)生和發(fā)展密切相關(guān),特別是與癌癥的關(guān)系備受關(guān)注。研究發(fā)現(xiàn)CCDC6的異常表達(dá)與甲狀腺癌、肺癌等多種癌癥的進(jìn)展有關(guān),同時(shí)也可能與神經(jīng)退行性疾病、心血管疾病等其他疾病存在關(guān)聯(lián)。因此,CCDC6成為生物學(xué)和醫(yī)學(xué)研究的重要靶點(diǎn),對(duì)于深入理解細(xì)胞調(diào)控機(jī)制以及疾病發(fā)生發(fā)展的分子機(jī)制具有重要意義。
熱銷產(chǎn)品
CCDC6 Antibody (CSB-PA623068LA01HU)
驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: CCDC6 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

IHC image of CSB-PA623068LA01HU diluted at 1:500 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA623068LA01HU diluted at 1:500 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with CSB-PA623068LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
CCDC6 Antibodies
CCDC6 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA623068LA01HU | CCDC6 Antibody | Human | ELISA, WB, IHC, IF |
CSB-PA623068LD01HU | CCDC6 Antibody, Biotin conjugated | Human | ELISA |
CCDC6 Proteins
CCDC6 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP623068HU CSB-EP623068HU CSB-BP623068HU CSB-MP623068HU CSB-EP623068HU-B |
Recombinant Human Coiled-coil domain-containing protein 6 (CCDC6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP623068HU(M) | Recombinant Human Coiled-coil domain-containing protein 6 (CCDC6) | E.coli |